Fat accumulates preferentially in the right rather than the left liver lobe in non-diabetic subjects

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Bian , H , Hakkarainen , A , Zhou , Y , Lundbom , N & Yki-Järvinen , H 2018 , ' Fat accumulates preferentially in the right rather than the left liver lobe in non-diabetic subjects ' , Digestive and Liver Disease , vol. 50 , no. 2 , pp. 168-174 . https://doi.org/10.1016/j.dld.2017.08.030

Title: Fat accumulates preferentially in the right rather than the left liver lobe in non-diabetic subjects
Author: Bian, Hua; Hakkarainen, Antti; Zhou, You; Lundbom, Nina; Yki-Järvinen, Hannele
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Department of Medicine
Date: 2018-02
Language: eng
Number of pages: 7
Belongs to series: Digestive and Liver Disease
ISSN: 1590-8658
URI: http://hdl.handle.net/10138/300965
Abstract: Aims: To examine the distribution of liver fat (LFAT) in non-diabetic subjects and test whether the fat in the right as compared to the left lobe correlates better with components of the metabolic syndrome or not. Methods: In this cross sectional study, we determined LFAT by H-1-MRS in the right lobe (LFAT%(MRS)), and by MRI (LFAT%(MRI)) in four regions of interest (ROIs 1-4, two in the right and two in the left lobe) in 97 non-diabetic subjects (age range 22-74 years, BMI 18-41 kg/m(2)) and compared the accuracy of LFAT(MRI) in the different ROIs in diagnosing non-alcoholic fatty liver disease (NAFLD) using areas under the receiver operator characteristic (AUROC) curves. Results: 38% of the subjects had NAFLD (LFAT%(MRS)). LFAT%(MRI) was significantly higher in the right (5.7 +/- 0.5%) than the left (5.1 +/- 0.4%) lobe (p <0.02). The AUROC for LFAT%(MRI) in the right lobe for diagnosing NAFLD was significantly better than that in the left lobe. The relationships between several metabolic parameters and LFAT%(MRI) in the left lobe were significantly worse than those for LFAT%(MRS) while there was no difference between LFAT%(MRS) and right lobe ROIs. Conclusions: Liver right lobe contains more fat and correlates better with components of the metabolic syndrome than the left in non-diabetic subjects. (C) 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Subject: Insulin
Metabolic syndrome
Obesity
MAGNETIC-RESONANCE-SPECTROSCOPY
TYPE-2 DIABETIC-PATIENTS
MORBIDLY OBESE-PATIENTS
METABOLIC SYNDROME
INSULIN THERAPY
IN-VIVO
DISEASE
QUANTIFICATION
STEATOSIS
GLUCOSE
3121 General medicine, internal medicine and other clinical medicine
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