Music-performance regulates microRNAs in professional musicians

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http://hdl.handle.net/10138/300971

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Nair , P S , Kuusi , T , Ahvenainen , M , Philips , A K & Järvelä , I 2019 , ' Music-performance regulates microRNAs in professional musicians ' , PeerJ , vol. 7 , 6660 . https://doi.org/10.7717/peerj.6660

Title: Music-performance regulates microRNAs in professional musicians
Author: Nair, Preethy Sasidharan; Kuusi, Tuire; Ahvenainen, Minna; Philips, Anju K.; Järvelä, Irma
Contributor: University of Helsinki, Irma Järvelä / Principal Investigator
University of Helsinki, Department of Medical and Clinical Genetics
University of Helsinki, Department of Medical and Clinical Genetics
University of Helsinki, Irma Järvelä / Principal Investigator
Date: 2019-03-29
Language: eng
Number of pages: 26
Belongs to series: PeerJ
ISSN: 2167-8359
URI: http://hdl.handle.net/10138/300971
Abstract: Musical training and performance require precise integration of multisensory and motor centres of the human brain and can be regarded as an epigenetic modifier of brain functions. Numerous studies have identified structural and functional differences between the brains of musicians and non-musicians and superior cognitive functions in musicians. Recently, music-listening and performance has also been shown to affect the regulation of several genes, many of which were identified in songbird singing. MicroRNAs affect gene regulation and studying their expression may give new insights into the epigenetic effect of music. Here, we studied the effect of 2 hours of classical music-performance on the peripheral blood microRNA expressions in professional musicians with respect to a control activity without music for the same duration. As detecting transcriptomic changes in the functional human brain remains a challenge for geneticists, we used peripheral blood to study music-performance induced microRNA changes and interpreted the results in terms of potential effects on brain function, based on the current knowledge about the microRNA function in blood and brain. We identified significant (FDR
Subject: MicroRNA
Sequencing
Music-performance
Gene regulation
Peripheral blood
Cognition
Perception
Neuroplasticity
HAIR-CELLS
MONOAMINE-OXIDASE
FOXP2 REGULATION
EXPRESSION
BRAIN
PLASTICITY
TRANSCRIPTOME
DATABASE
EXERCISE
BEHAVIOR
3111 Biomedicine
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