Early-onset tobacco use and suicide-related behavior - A prospective study from adolescence to young adulthood

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Korhonen , T , Sihvola , E , Latvala , A , Dick , D M , Pulkkinen , L , Nurnberger , J , Rose , R J & Kaprio , J 2018 , ' Early-onset tobacco use and suicide-related behavior - A prospective study from adolescence to young adulthood ' , Addictive Behaviors , vol. 79 , pp. 32-38 . https://doi.org/10.1016/j.addbeh.2017.12.008

Title: Early-onset tobacco use and suicide-related behavior - A prospective study from adolescence to young adulthood
Author: Korhonen, Tellervo; Sihvola, Elina; Latvala, Antti; Dick, Danielle M.; Pulkkinen, Lea; Nurnberger, John; Rose, Richard J.; Kaprio, Jaakko
Contributor organization: Institute for Molecular Medicine Finland
Department of Public Health
University of Helsinki
Department of Psychiatry
HUS Psychiatry
Genetic Epidemiology
Date: 2018-04
Language: eng
Number of pages: 7
Belongs to series: Addictive Behaviors
ISSN: 0306-4603
DOI: https://doi.org/10.1016/j.addbeh.2017.12.008
URI: http://hdl.handle.net/10138/300986
Abstract: Background: Developmental relationships between tobacco use and suicide-related behaviors (SRB) remain unclear. Our objective was to investigate the longitudinal associations of tobacco use in adolescence and SRB in adulthood. Methods: Using a prospective design, we examined whether tobacco use in adolescence is associated with SRB (intentional self-injury, suicide ideation) in young adulthood in a population-based sample of 1330 twins (626 males, 704 females). The baseline and follow-up data were collected by professionally administered semi-structured poly-diagnostic interviews at ages 14 and 22, respectively. Results: After adjusting for multiple potential confounders, those who reported early-onset of regular tobacco use had a significantly increased risk for intentional self-injury, such as cutting or burning, at age 22 (adjusted odds ratio[AOR] 4.57, 95% CI 1.93-10.8) in comparison to those who had not at all initiated tobacco use. Also, daily cigarette smoking at baseline was associated with future intentional self-injury (AOR 4.45, 95% CI 2.04-9.70). Early-onset tobacco use was associated with suicidal ideation in females (AOR 3.69, 95% CI 1.56-8.72) but not in males. Considering any SRB, baseline daily smokers (AOR 2.13, 95% CI 1.12-4.07) and females with early onset of regular tobacco use (AOR 3.97, 95% CI 1.73-9.13) had an increased likelihood. Within-family analyses among twin pairs discordant for exposure and outcome controlling for familial confounds showed similar, albeit statistically non-significant, associations. Conclusion: Early-onset tobacco use in adolescence is longitudinally associated with SRB (intentional self-injury and/or suicide ideation) in young adulthood, particularly among females. Further investigation may reveal whether this association has implications for prevention of SRB in adolescence and young adulthood.
Subject: Self-injury
Suicidal ideation
515 Psychology
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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