Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

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http://hdl.handle.net/10138/301013

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Shapiguzov , A , Vainonen , J , Hunter , K A , Tossavainen , H P M , Tiwari , A , Järvi , S , Hellman , M H , Aarabi , F , Alseekh , S , Wybouw , B , Van Der Kelen , K , Nikkanen , L , Krasensky-Wrzaczek , J , Sipari , N H , Keinänen , M , Tyystjaervi , E , Rintamäki , E , De Rybel , B , Salojärvi , J T , Van Breusegem , F , Fernie , A R , Brosche , M J , Permi , P E I , Aro , E-M , Wrzaczek , M A & Kangasjärvi , J S 2019 , ' Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors ' , eLife , vol. 8 , e43284 . https://doi.org/10.7554/eLife.43284

Title: Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors
Author: Shapiguzov, Alexey; Vainonen, Julia; Hunter, Kerri Alyssa; Tossavainen, Helena P M; Tiwari, Arjun; Järvi, Sari; Hellman, Maarit Helena; Aarabi, Fayezeh; Alseekh, Saleh; Wybouw, Brecht; Van Der Kelen, Katrien; Nikkanen, Lauri; Krasensky-Wrzaczek, Julia; Sipari, Nina Hannele; Keinänen, Markku; Tyystjaervi, Esa; Rintamäki, Eevi; De Rybel, Bert; Salojärvi, Jarkko Tapani; Van Breusegem, Frank; Fernie, Alisdair R.; Brosche, Mikael Johan; Permi, Perttu Esko Ilari; Aro, Eva-Mari; Wrzaczek, Michael Alois; Kangasjärvi, Jaakko Sakari
Contributor: University of Helsinki, Plant ROS-Signalling
University of Helsinki, Plant ROS-Signalling
University of Helsinki, Receptor-Ligand Signaling Group
University of Helsinki, Institute of Biotechnology
University of Helsinki, University of Jyväskylä
University of Helsinki, Plant ROS-Signalling
University of Helsinki, Organismal and Evolutionary Biology Research Programme
University of Helsinki, Viikki Plant Science Centre (ViPS)
University of Helsinki, Organismal and Evolutionary Biology Research Programme
University of Helsinki, Perttu Permi / Principal Investigator
University of Helsinki, Viikki Plant Science Centre (ViPS)
University of Helsinki, Organismal and Evolutionary Biology Research Programme
Date: 2019-02-15
Language: eng
Number of pages: 35
Belongs to series: eLife
ISSN: 2050-084X
URI: http://hdl.handle.net/10138/301013
Abstract: Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.
Subject: ALTERNATIVE OXIDASES
CELL-DEATH
CYCLIC ELECTRON FLOW
ENZYME-ACTIVITIES
GENES-ENCODING MITOCHONDRIAL
OXIDATIVE STRESS-RESPONSE
PLANT-MITOCHONDRIA
PROTEIN COMPLEXES
RETROGRADE REGULATION
SIGNALING PATHWAYS
1183 Plant biology, microbiology, virology
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