Sera of Peruvians with fever of unknown origins include viral nucleic acids from non-vertebrate hosts

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http://hdl.handle.net/10138/301081

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Phan , T G , del Valle Mendoza , J , Sadeghi , M , Altan , E , Deng , X & Delwart , E 2018 , ' Sera of Peruvians with fever of unknown origins include viral nucleic acids from non-vertebrate hosts ' , Virus Genes , vol. 54 , no. 1 , pp. 33-40 . https://doi.org/10.1007/s11262-017-1514-3

Title: Sera of Peruvians with fever of unknown origins include viral nucleic acids from non-vertebrate hosts
Author: Phan, Tung Gia; del Valle Mendoza, Juana; Sadeghi, Mohammadreza; Altan, Eda; Deng, Xutao; Delwart, Eric
Contributor: University of Helsinki, Department of Virology
Date: 2018-02
Language: eng
Number of pages: 8
Belongs to series: Virus Genes
ISSN: 0920-8569
URI: http://hdl.handle.net/10138/301081
Abstract: Serum samples collected from 88 Peruvians with unexplained fever were analyzed for viral sequences using metagenomics. Nucleic acids of anelloviruses, pegivirus A (GBV-C), HIV, Dengue virus, and Oropouche virus were detected. We also characterized from two sera the RNA genomes of new species of partitivirus and dicistrovirus belonging to viral families known to infect fungi or arthropod, respectively. Genomic DNA of a putative fungal cellular host could be PCR amplified from the partitivirus-containing serum sample. The detection in human serum of nucleic acids from viral families not known to infect vertebrates may indicate contamination during sample collection and aliquoting or human infection by their presumed cellular host, here a fungus. The role, if any, of the non-vertebrate infecting viruses detected in serum in inducing fever is unknown.
Subject: Dicistrovirus
Partitivirus
Fever
Metagenomics
Sera
OROPOUCHE VIRUS
TAURA-SYNDROME
PROTEIN
VIROME
PCR
DICISTROVIRUSES
INFECTIONS
SEQUENCES
DNA
3111 Biomedicine
1184 Genetics, developmental biology, physiology
1183 Plant biology, microbiology, virology
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