Anti-neuronal anti-bodies in patients with early psychosis

Show full item record



Permalink

http://hdl.handle.net/10138/301089

Citation

Mantere , O , Saarela , M , Kieseppä , T , Raij , T , Mäntylä , T , Lindgren , M , Rikandi , E , Stoecker , W , Teegen , B & Suvisaari , J 2018 , ' Anti-neuronal anti-bodies in patients with early psychosis ' , Schizophrenia Research , vol. 192 , pp. 404-407 . https://doi.org/10.1016/j.schres.2017.04.027

Title: Anti-neuronal anti-bodies in patients with early psychosis
Author: Mantere, O.; Saarela, M.; Kieseppä, T.; Raij, T.; Mäntylä, T.; Lindgren, M.; Rikandi, E.; Stoecker, W.; Teegen, B.; Suvisaari, J.
Contributor: University of Helsinki, Neurologian yksikkö
University of Helsinki, Department of Psychiatry
University of Helsinki, Clinicum
Date: 2018-02
Language: eng
Number of pages: 4
Belongs to series: Schizophrenia Research
ISSN: 0920-9964
URI: http://hdl.handle.net/10138/301089
Abstract: It may be challenging to distinguish autoimmune encephalitis associated with anti-neuronal autoantibodies from primary psychiatric disorders. Here, serum was drawn from patients with a first-episode psychosis (n = 70) or a clinical high-risk for psychosis (n = 6) and controls (n = 34). We investigated the serum prevalence of 24 antineuronal autoantibodies: IgG antibodies for anti-N-methyl-D-aspartate-type glutamate receptor (anti-NMDAR), glutamate and gamma-aminobutyric acid alpha and beta receptors (GABA-a, GABA-b), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA), glycine receptor (GlyR), metabotropic glutamate receptor 1 and 5 (mGluR1, mGluR5), anti-Tr/Delta/notch-like epidermal growth factor-related receptor (DNER), contactin-associated protein-like 2 (CASPR2), myelin oligodendrocyte glycoprotein (MOG), glutamic acid decarboxylase-65 (GAD65), collapsin response mediator protein 5/crossveinless-2 (CV2), aquaporin-4 (AQP4), anti-dipeptidyl-peptidase-like protein-6 (DPPX), type 1 anti-neuronal nuclear antibody (ANNA-1, Hu), Ri, Yo, IgLON5, Ma2, zinc finger protein 4 (ZIC4), Rho GTPase-activating protein 26, amphiphysin, and recoverin, as well as IgA and IgM for dopamine-2-receptor (DRD2). Anti-NMDA IgG antibodies were positive with serum titer 1:320 in one patient with a clinical high risk for psychosis. He did not receive a diagnosis of encephalitis after comprehensive neurological evaluation. All other antineuronal autoantibodies were negative and there were no additional findings with immunohistochemistry of brain issues. (C) 2017 Elsevier B.V. All rights reserved.
Subject: N-methyl D-aspartate (NMDA) receptor
Anti-glycine receptor
Anti-neuronal antibodies
Autoimmunity
Clinical high risk of psychosis
First episode psychosis
NMDA-RECEPTOR ENCEPHALITIS
AUTOIMMUNE ENCEPHALITIS
1ST EPISODE
SCHIZOPHRENIA
AUTOANTIBODIES
DIAGNOSIS
PREVALENCE
SYMPTOMS
3124 Neurology and psychiatry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0920996417302141_main.pdf 268.7Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record