Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response

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Schwarz , E , Maukonen , J , Hyytiäinen , T , Kieseppä , T , Oresic , M , Sabunciyan , S , Mantere , O , Saarela , M , Yolken , R & Suvisaari , J 2018 , ' Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response ' , Schizophrenia Research , vol. 192 , pp. 398-403 . https://doi.org/10.1016/j.schres.2017.04.017

Title: Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response
Author: Schwarz, Emanuel; Maukonen, Johanna; Hyytiäinen, Tiina; Kieseppä, Tuula; Oresic, Matej; Sabunciyan, Sarven; Mantere, Outi; Saarela, Maria; Yolken, Robert; Suvisaari, Jaana
Contributor: University of Helsinki, Department of Psychiatry
Date: 2018-02
Language: eng
Number of pages: 6
Belongs to series: Schizophrenia Research
ISSN: 0920-9964
URI: http://hdl.handle.net/10138/301092
Abstract: The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12 months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12 months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission. (C) 2017 Elsevier B.V. All rights reserved.
Subject: Schizophrenia
Microbiome
Psychosis
Response
AUTOIMMUNE-DISEASES
RISK-FACTORS
INTESTINAL MICROBIOTA
SEVERE INFECTIONS
BIPOLAR DISORDER
FECAL MICROBIOTA
GUT MICROBIOME
SCHIZOPHRENIA
BRAIN
MARKERS
3124 Neurology and psychiatry
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