Novel activities of safe-in-human broad-spectrum antiviral agents

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Ianevski , A , Zusinaite , E , Kuivanen , S , Strand , M , Lysvand , H , Teppor , M , Kakkola , L , Paavilainen , H , Laajala , M , Kallio-Kokko , H , Valkonen , M , Kantele , A , Telling , K , Lutsar , I , Letjuka , P , Metelitsa , N , Oksenych , V , Bjørås , M , Nordbø , S A , Dumpis , U , Vitkauskiene , A , Öhrmalm , C , Bondeson , K , Bergqvist , A , Aittokallio , T , Cox , R J , Evander , M , Hukkanen , V , Marjomaki , V , Julkunen , I , Vapalahti , O , Tenson , T , Merits , A & Kainov , D 2018 , ' Novel activities of safe-in-human broad-spectrum antiviral agents ' , Antiviral Research , vol. 154 , pp. 174-182 . https://doi.org/10.1016/j.antiviral.2018.04.016

Title: Novel activities of safe-in-human broad-spectrum antiviral agents
Author: Ianevski, Aleksandr; Zusinaite, Eva; Kuivanen, Suvi; Strand, Mårten; Lysvand, Hilde; Teppor, Mona; Kakkola, Laura; Paavilainen, Henrik; Laajala, Mira; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Bjørås, Magnar; Nordbø, Svein Arne; Dumpis, Uga; Vitkauskiene, Astra; Öhrmalm, Christina; Bondeson, Kåre; Bergqvist, Anders; Aittokallio, Tero; Cox, Rebecca J.; Evander, Magnus; Hukkanen, Veijo; Marjomaki, Varpu; Julkunen, Ilkka; Vapalahti, Olli; Tenson, Tanel; Merits, Andres; Kainov, Denis
Contributor organization: Medicum
Viral Zoonosis Research Unit
Department of Virology
University of Helsinki
Clinicum
Department of Medicine
Department of Bacteriology and Immunology
Anu Kantele-Häkkinen Research Group
Tero Aittokallio / Principal Investigator
Bioinformatics
Institute for Molecular Medicine Finland
Veterinary Microbiology and Epidemiology
Veterinary Biosciences
Olli Pekka Vapalahti / Principal Investigator
HUS Perioperative, Intensive Care and Pain Medicine
HUS Inflammation Center
Date: 2018-06
Language: eng
Number of pages: 9
Belongs to series: Antiviral Research
ISSN: 0166-3542
DOI: https://doi.org/10.1016/j.antiviral.2018.04.016
URI: http://hdl.handle.net/10138/301108
Abstract: Abstract According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, investigational and experimental antiviral agents, which are safe in man, and identified 59 compounds that target at least three viral diseases. We tested 55 of these compounds against eight different RNA and DNA viruses. We found novel activities for dalbavancin against echovirus 1, ezetimibe against human immunodeficiency virus 1 and Zika virus, as well as azacitidine, cyclosporine, minocycline, oritavancin and ritonavir against Rift valley fever virus. Thus, the spectrum of antiviral activities of existing antiviral agents could be expanded towards other viral diseases.
Subject: 3111 Biomedicine
317 Pharmacy
ZIKA VIRUS-INFECTION
HEPATITIS-C VIRUS
INFLUENZA-A VIRUS
LIVER-TRANSPLANTATION
APPROVED DRUGS
CELL-CULTURE
MOUSE MODEL
ECHOVIRUS 1
INHIBITORS
ENTRY
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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