Laser-Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Healing of Infected Chronic Nonhealing Wounds

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Qiao , Y , Ping , Y , Zhang , H , Zhou , B , Liu , F , Yu , Y , Xie , T , Li , W , Zhong , D , Zhang , Y , Yao , K , Almeida Santos , H & Zhou , M 2019 , ' Laser-Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Healing of Infected Chronic Nonhealing Wounds ' , ACS Applied Materials & Interfaces , vol. 11 , no. 4 , pp. 3809–3822 . https://doi.org/10.1021/acsami.8b21766

Title: Laser-Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Healing of Infected Chronic Nonhealing Wounds
Author: Qiao, Yue; Ping, Yuan; Zhang, Hongbo; Zhou, Bo; Liu, Fengyong; Yu, Yinhui; Xie, Tingting; Li, Wanli; Zhong, Danni; Zhang, Yuezhou; Yao, Ke; Almeida Santos, Helder; Zhou, Min
Contributor organization: Drug Research Program
Division of Pharmaceutical Chemistry and Technology
Nanomedicines and Biomedical Engineering
Helsinki Institute of Life Science HiLIFE
Date: 2019-01-30
Language: eng
Number of pages: 14
Belongs to series: ACS Applied Materials & Interfaces
ISSN: 1944-8244
DOI: https://doi.org/10.1021/acsami.8b21766
URI: http://hdl.handle.net/10138/301154
Abstract: Chronic nonhealing wounds have imposed serious challenges in the clinical practice, especially for the patients infected with multidrug-resistant microbes. Herein, we developed an ultrasmall copper sulfide (covellite) nanodots (CuS NDs) based dual functional nanosystem to cure multidrug-resistant bacteria-infected chronic nonhealing wound. The nanosystem could eradicate multidrug-resistant bacteria and expedite wound healing simultaneously owing to the photothermal effect and remote control of copper-ion release. The antibacterial results indicated that the combination treatment of photothermal CuS NDs with photothermal effect initiated a strong antibacterial effect for drug-resistant pathogens including methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase Escherichia coli both in vitro and in vivo. Meanwhile, the released Cu2+ could promote fibroblast cell migration and endothelial cell angiogenesis, thus accelerating wound-healing effects. In MRSA-infected diabetic mice model, the nanosystem exhibited synergistic wound healing effect of infectious wounds in vivo and demonstrated negligible toxicity and nonspecific damage to major organs. The combination of ultrasmall CuS NDs with photothermal therapy displayed enhanced therapeutic efficacy for chronic nonhealing wound in multidrug-resistant bacterial infections, which may represent a promising class of antibacterial strategy for clinical translation.
Subject: AGENT
ANGIOGENESIS
GOLD NANOPARTICLES
GRAPHENE
NANOCRYSTALS
NANODIAGNOSTICS
PHOTOTHERMAL ABLATION
SILVER
THERAPY
antibacterial effect
chronic nonhealing wound
copper sulfide nanodots
multidrug-resistant bacteria
photothermal effects
221 Nano-technology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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