Chemical analysis using 3D printed glass microfluidics

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http://hdl.handle.net/10138/301164

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Gal-Or , E , Gershoni , Y , Scotti , G , Nilsson , S M E , Saarinen , J K S , Jokinen , V P , Strachan , C J , Boije af Gennäs , P G , Yli-Kauhaluoma , J T & Kotiaho , A A T 2019 , ' Chemical analysis using 3D printed glass microfluidics ' , Analytical Methods , vol. 11 , no. 13 , pp. 1802-1810 . https://doi.org/10.1039/C8AY01934G

Title: Chemical analysis using 3D printed glass microfluidics
Author: Gal-Or, Eran; Gershoni, Yaniv; Scotti, Gianmario; Nilsson, Sofia Märta Elisabeth; Saarinen, Jukka Kalle Samuel; Jokinen, Ville Petteri; Strachan, Clare Joanna; Boije af Gennäs, Per Gustav; Yli-Kauhaluoma, Jari Tapani; Kotiaho, Ahti Antti Tapio
Contributor organization: Division of Pharmaceutical Chemistry and Technology
Drug Research Program
Faculty of Pharmacy
Preclinical Drug Formulation and Analysis group
Formulation and industrial pharmacy
Clare Strachan / Research Group
Pharmaceutical Design and Discovery group
Jari Yli-Kauhaluoma / Principal Investigator
Tapio Kotiaho / Principal Investigator
Department of Chemistry
Date: 2019-04-07
Language: eng
Number of pages: 9
Belongs to series: Analytical Methods
ISSN: 1759-9660
DOI: https://doi.org/10.1039/C8AY01934G
URI: http://hdl.handle.net/10138/301164
Abstract: Additive manufacturing (3D printing) is a disruptive technology that is changing production systems globally. In addition, microfluidic devices are increasingly being used for chemical analysis and continuous production of chemicals. Printing of materials such as polymers and metals is already a reality, but additive manufacturing of glass for microfluidic systems has received minor attention. We characterize microfluidic devices (channel cross-section dimensions down to a scale of 100 mm) that have been produced by additive manufacturing of molten soda-lime glass in tens of minutes and report their mass spectrometric and Raman spectroscopic analysis examples. The functionality of a microfluidic glass microreactor is shown with online mass spectrometric analysis of linezolid synthesis. Additionally, the performance of a direct infusion device is demonstrated by mass spectrometric analysis of drugs. Finally, the excellent optical quality of the glass structures is demonstrated with in-line Raman spectroscopic measurements. Our results promise a bright future for additively manufactured glass microdevices in diverse fields of science.
Subject: CHANNEL
CHEMISTRY
FABRICATION
LASER
RAMAN-SPECTROSCOPY
TOOL
116 Chemical sciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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