Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons

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http://hdl.handle.net/10138/301216

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Kala , K , Haugas , M , Lilleväli , K , Guimera , J , Wurst , W , Salminen , M & Partanen , J 2009 , ' Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons ' , Development , vol. 136 , no. 2 , pp. 253-262 . https://doi.org/10.1242/dev.029900

Title: Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons
Author: Kala, Kaia; Haugas, Maarja; Lilleväli, Kersti; Guimera, Jordi; Wurst, Wolfgang; Salminen, Marjo; Partanen, Juha
Contributor: University of Helsinki, Institute of Biotechnology (-2009)
University of Helsinki, University of Tartu
University of Helsinki, Veterinary Biosciences
University of Helsinki, Institute of Biotechnology (-2009)
Date: 2009
Language: eng
Number of pages: 10
Belongs to series: Development
ISSN: 0950-1991
URI: http://hdl.handle.net/10138/301216
Abstract: Midbrain GABAergic neurons control several aspects of behavior, but regulation of their development and diversity is poorly understood. Here, we further refine the midbrain regions active in GABAergic neurogenesis and show their correlation with the expression of the transcription factor Gata2. Using tissue-specific inactivation and ectopic expression, we show that Gata2 regulates GABAergic neuron development in the mouse midbrain, but not in rhombomere 1, where it is needed in the serotonergic lineage. Without Gata2, all the precursors in the embryonic midbrain fail to activate GABAergic neuron-specific gene expression and instead switch to a glutamatergic phenotype. Surprisingly, this fate switch is also observed throughout the neonatal midbrain, except for the GABAergic neurons located in the ventral dopaminergic nuclei, suggesting a distinct developmental pathway for these neurons. These studies identify Gata2 as an essential post-mitotic selector gene of the GABAergic neurotransmitter identity and demonstrate developmental heterogeneity of GABAergic neurons in the midbrain.
Subject: 1184 Genetics, developmental biology, physiology
1182 Biochemistry, cell and molecular biology
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