Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons

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dc.contributor.author Kala, Kaia
dc.contributor.author Haugas, Maarja
dc.contributor.author Lilleväli, Kersti
dc.contributor.author Guimera, Jordi
dc.contributor.author Wurst, Wolfgang
dc.contributor.author Salminen, Marjo
dc.contributor.author Partanen, Juha
dc.date.accessioned 2019-04-25T08:50:01Z
dc.date.available 2019-04-25T08:50:01Z
dc.date.issued 2009
dc.identifier.citation Kala , K , Haugas , M , Lilleväli , K , Guimera , J , Wurst , W , Salminen , M & Partanen , J 2009 , ' Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons ' , Development , vol. 136 , no. 2 , pp. 253-262 . https://doi.org/10.1242/dev.029900
dc.identifier.other PURE: 1145529
dc.identifier.other PURE UUID: e78b7608-fd18-4396-ad3b-1659bf24ce2e
dc.identifier.other dawa_publication: 189141
dc.identifier.other WOS: 000261927500009
dc.identifier.other Scopus: 62349137096
dc.identifier.other ORCID: /0000-0003-0696-6845/work/29734762
dc.identifier.uri http://hdl.handle.net/10138/301216
dc.description.abstract Midbrain GABAergic neurons control several aspects of behavior, but regulation of their development and diversity is poorly understood. Here, we further refine the midbrain regions active in GABAergic neurogenesis and show their correlation with the expression of the transcription factor Gata2. Using tissue-specific inactivation and ectopic expression, we show that Gata2 regulates GABAergic neuron development in the mouse midbrain, but not in rhombomere 1, where it is needed in the serotonergic lineage. Without Gata2, all the precursors in the embryonic midbrain fail to activate GABAergic neuron-specific gene expression and instead switch to a glutamatergic phenotype. Surprisingly, this fate switch is also observed throughout the neonatal midbrain, except for the GABAergic neurons located in the ventral dopaminergic nuclei, suggesting a distinct developmental pathway for these neurons. These studies identify Gata2 as an essential post-mitotic selector gene of the GABAergic neurotransmitter identity and demonstrate developmental heterogeneity of GABAergic neurons in the midbrain. sv
dc.description.abstract Midbrain GABAergic neurons control several aspects of behavior, but regulation of their development and diversity is poorly understood. Here, we further refine the midbrain regions active in GABAergic neurogenesis and show their correlation with the expression of the transcription factor Gata2. Using tissue-specific inactivation and ectopic expression, we show that Gata2 regulates GABAergic neuron development in the mouse midbrain, but not in rhombomere 1, where it is needed in the serotonergic lineage. Without Gata2, all the precursors in the embryonic midbrain fail to activate GABAergic neuron-specific gene expression and instead switch to a glutamatergic phenotype. Surprisingly, this fate switch is also observed throughout the neonatal midbrain, except for the GABAergic neurons located in the ventral dopaminergic nuclei, suggesting a distinct developmental pathway for these neurons. These studies identify Gata2 as an essential post-mitotic selector gene of the GABAergic neurotransmitter identity and demonstrate developmental heterogeneity of GABAergic neurons in the midbrain. fi
dc.description.abstract Midbrain GABAergic neurons control several aspects of behavior, but regulation of their development and diversity is poorly understood. Here, we further refine the midbrain regions active in GABAergic neurogenesis and show their correlation with the expression of the transcription factor Gata2. Using tissue-specific inactivation and ectopic expression, we show that Gata2 regulates GABAergic neuron development in the mouse midbrain, but not in rhombomere 1, where it is needed in the serotonergic lineage. Without Gata2, all the precursors in the embryonic midbrain fail to activate GABAergic neuron-specific gene expression and instead switch to a glutamatergic phenotype. Surprisingly, this fate switch is also observed throughout the neonatal midbrain, except for the GABAergic neurons located in the ventral dopaminergic nuclei, suggesting a distinct developmental pathway for these neurons. These studies identify Gata2 as an essential post-mitotic selector gene of the GABAergic neurotransmitter identity and demonstrate developmental heterogeneity of GABAergic neurons in the midbrain. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Development
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 1184 Genetics, developmental biology, physiology
dc.subject 1182 Biochemistry, cell and molecular biology
dc.title Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons en
dc.type Article
dc.contributor.organization Institute of Biotechnology (-2009)
dc.contributor.organization Veterinary Biosciences
dc.contributor.organization Developmental neurogenetics
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1242/dev.029900
dc.relation.issn 0950-1991
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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