The association between toxoplasma and the psychosis continuum in a general population setting

Show full item record



Permalink

http://hdl.handle.net/10138/301254

Citation

Lindgren , M , Torniainen-Holm , M , Härkänen , T , Dickerson , F , Yolken , R H & Suvisaari , J 2018 , ' The association between toxoplasma and the psychosis continuum in a general population setting ' , Schizophrenia Research , vol. 193 , pp. 329-335 . https://doi.org/10.1016/j.schres.2017.06.052

Title: The association between toxoplasma and the psychosis continuum in a general population setting
Author: Lindgren, Maija; Torniainen-Holm, Minna; Härkänen, Tommi; Dickerson, Faith; Yolken, Robert H.; Suvisaari, Jaana
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
Date: 2018-03
Language: eng
Number of pages: 7
Belongs to series: Schizophrenia Research
ISSN: 0920-9964
URI: http://hdl.handle.net/10138/301254
Abstract: Toxoplasma gondii infection is associated with increased risk for psychosis. However, the possible association between T. gondii and psychotic-like symptoms in the general adult population is unknown. We investigated whether T. gondii is associated with psychotic-like symptoms and psychosis diagnoses using data from Health 2000, a large cross-sectional health survey of the Finnish general population aged 30 and above. Seropositivity to toxoplasma was defined as a cutoff of 50 IU/ml of IgG antibodies. Lifetime psychotic-like symptoms were identified with section G of the Composite International Diagnostic Interview, Munich version (M-CIDI). Symptoms were considered clinically relevant if they caused distress or help-seeking or there were at least three of them. Lifetime psychotic disorders were screened from the sample and were diagnosed with DSM-IV using SCID-I interview and information from medical records. All data were available for 5906 participants. We adjusted for variables related to T. gondii seropositivity (age, gender, education, region of residence, cat ownership, and C-reactive protein measuring inflammation) in regression models. We found that T. gondii seropositivity was significantly associated with clinically relevant psychotic-like symptoms (OR 1.77, p = 0.001) and with the number of psychotic-like symptoms (IRR = 1.55, p = 0.001). The association between toxoplasma and diagnosed psychotic disorders did not reach statistical significance (OR 1.45 for schizophrenia). In a large sample representing the whole Finnish adult population, we found that serological evidence of toxoplasma infection predicted psychotic-like symptoms, independent of demographic factors and levels of C-reactive protein. Toxoplasma infection may be a risk factor for manifestation of psychotic-like symptoms. (c) 2017 Elsevier B.V. All rights reserved.
Subject: oxoplasma gondii
Population
Psychotic disorder
Psychotic-like symptom
C-reactive protein
INFECTIOUS AGENTS
HIGH-RISK
SCHIZOPHRENIA
GONDII
METAANALYSIS
INDIVIDUALS
ANTIBODIES
DISORDERS
DISEASES
3124 Neurology and psychiatry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0920996417303912_main.pdf 746.1Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record