Evaluation of the budding and depth of invasion (BD) model in oral tongue cancer biopsies

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Almangush , A , Leivo , I , Siponen , M , Sundquist , E , Mroueh , R , Mäkitie , A A , Soini , Y , Haglund , C , Nieminen , P & Salo , T 2018 , ' Evaluation of the budding and depth of invasion (BD) model in oral tongue cancer biopsies ' , Virchows Archiv , vol. 472 , no. 2 , pp. 231-236 . https://doi.org/10.1007/s00428-017-2212-1

Title: Evaluation of the budding and depth of invasion (BD) model in oral tongue cancer biopsies
Author: Almangush, Alhadi; Leivo, Ilmo; Siponen, Maria; Sundquist, Elias; Mroueh, Rayan; Mäkitie, Antti A.; Soini, Ylermi; Haglund, Caj; Nieminen, Pentti; Salo, Tuula
Contributor organization: Oral and Maxillofacial Surgery
Department of Pathology
Medicum
University of Helsinki
Clinicum
Korva-, nenä- ja kurkkutautien klinikka
Translational Cancer Biology (TCB) Research Programme
Department of Surgery
II kirurgian klinikka
Research Programs Unit
HUSLAB
Department of Oral and Maxillofacial Diseases
HUS Head and Neck Center
HUS Abdominal Center
Date: 2018-02
Language: eng
Number of pages: 6
Belongs to series: Virchows Archiv
ISSN: 0945-6317
DOI: https://doi.org/10.1007/s00428-017-2212-1
URI: http://hdl.handle.net/10138/301257
Abstract: It is of great clinical importance to identify simple prognostic markers from preoperative biopsies that could guide treatment planning. Here, we compared tumor budding (B), depth of invasion (D), and the combined scores (i.e., budding and depth of invasion (BD) histopathologic model) in preoperative biopsies and the corresponding postoperative specimens of oral tongue squamous cell carcinoma (OTSCC). Tumor budding and depth of invasion were evaluated in the pre- and postoperative samples from 100 patients treated for OTSCC. Sensitivity and specificity statistics were used. Our results showed statistically significant (P <0.001) relationship between pre- and postoperative BD scores. There was an agreement between the pre- and postoperative BD model scores in 83 cases (83%) with 57.1% sensitivity (95% CI 39.4 to 73.7%) and 96.9% specificity (95% CI 89.3 to 99.6%). Our findings suggest that the BD model, analyzed from representative biopsies, could be used for the treatment planning of OTSCC.
Subject: Oral tongue cancer
Tumor budding
Tumor depth
BD model
Prognosis
SQUAMOUS-CELL CARCINOMA
EPITHELIAL-MESENCHYMAL TRANSITION
TUMOR THICKNESS
PROGNOSTIC VALUE
NODAL METASTASIS
POOR-PROGNOSIS
WORST PATTERN
STAGE
METAANALYSIS
EXPRESSION
3111 Biomedicine
313 Dentistry
3122 Cancers
3125 Otorhinolaryngology, ophthalmology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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