Oral lichen sclerosus : a systematic review of reported cases and two new cases

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Kakko , T , Salo , T & Siponen , M K 2018 , ' Oral lichen sclerosus : a systematic review of reported cases and two new cases ' , International Journal of Dermatology , vol. 57 , no. 5 , pp. 521-528 . https://doi.org/10.1111/ijd.13870

Title: Oral lichen sclerosus : a systematic review of reported cases and two new cases
Author: Kakko, Tuomas; Salo, Tuula; Siponen, Maria K.
Contributor: University of Helsinki, Clinicum
Date: 2018-05
Language: eng
Number of pages: 8
Belongs to series: International Journal of Dermatology
ISSN: 0011-9059
URI: http://hdl.handle.net/10138/301262
Abstract: Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease with uncertain etiology. It occurs as white plaque-like lesions mostly in the anogenital skin. Oral mucosal involvement is extremely rare. This study aims to summarize the features of published oral lichen sclerosus (OLS) and two new cases. A systematic search of the English literature from 1955 to 2016 was performed in MEDLINE, Scopus, and Web of Science, and cross-references were searched manually. Search phrases included lichen sclerosus, mouth, oral, lip, palate, floor of mouth, tongue, gingiva, buccal mucosa, and mouth diseases. Cases with clinical and histopathological confirmation of diagnosis of OLS were included. A total of 41 (39 published and 2 new) histologically confirmed OLS cases were available. The median age of OLS patients was 31 years, and 66% of the patients were female. Most of the OLS lesions were asymptomatic. They were located in the labial mucosa (n = 20), lip (n = 15), buccal mucosa (n = 14), gingiva (n = 12), tongue (n = 12), and palate (n = 7). OLS is rare and typically presents as asymptomatic, white, plaque-like lesions. Malignant transformation of preexisting OLS has not been reported.
Subject: EXTRACELLULAR-MATRIX PROTEIN-1
SQUAMOUS-CELL CARCINOMA
RARE CASE-REPORT
ET-ATROPHICUS
AUTOIMMUNE-DISEASE
MUCOSA
ASSOCIATION
AUTOANTIBODIES
SUSCEPTIBILITY
ANTIGENS
3121 General medicine, internal medicine and other clinical medicine
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