Expression of hormone receptors in oropharyngeal squamous cell carcinoma

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Mohamed , H , Aro , K , Jouhi , L , Makitie , A , Remes , S , Haglund , C , Atula , T & Hagstrom , J 2018 , ' Expression of hormone receptors in oropharyngeal squamous cell carcinoma ' , European Archives of Oto-Rhino-Laryngology , vol. 275 , no. 5 , pp. 1289-1300 . https://doi.org/10.1007/s00405-018-4949-9

Title: Expression of hormone receptors in oropharyngeal squamous cell carcinoma
Author: Mohamed, Hesham; Aro, Katri; Jouhi, Lauri; Makitie, Antti; Remes, Satu; Haglund, Caj; Atula, Timo; Hagstrom, Jaana
Contributor: University of Helsinki, Department of Pathology
University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka
University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka
University of Helsinki, Clinicum
University of Helsinki, Department of Pathology
University of Helsinki, Translational Cancer Biology (TCB) Research Programme
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2018-05
Language: eng
Number of pages: 12
Belongs to series: European Archives of Oto-Rhino-Laryngology
ISSN: 0937-4477
URI: http://hdl.handle.net/10138/301301
Abstract: Hormone receptors play an important role in many types of cancers. Alongside factors associated with human papillomavirus (HPV) infection, hormonal receptors may impact the tumorigenesis of oropharyngeal cancer. This study consists of 199 consecutive oropharyngeal squamous cell carcinoma (OPSCC) patients diagnosed and treated with a curative intent. We examined androgen (AR), estrogen (ER; both alpha and beta), and progesterone receptor (PR) expressions using immunohistochemistry comparing tumor and patient characteristics. AR was expressed in 16%, PR in 27% and ER-beta in 63% of the tumors. HPV- and p16-positive tumors expressed more AR and less PR than their negative counterparts. High PR expression was associated with poor disease-specific and locoregional recurrence-free survival. AR, PR, and ER-beta are expressed in OPSCC, and AR and PR expressions are associated with HPV and p16 status. Furthermore, PR appears to have prognostic significance. This may allow us to investigate the role of anti-hormone receptors in the treatment of OPSCC.
Subject: Oropharynx
Human papillomavirus (HPV)
Androgen receptor
Estrogen receptor
Progesterone receptor
PROSTATE-CANCER PATIENTS
ANDROGEN-RECEPTOR
PROGESTERONE-RECEPTORS
HUMAN-PAPILLOMAVIRUS
LARYNGEAL CARCINOMA
CLINICOPATHOLOGICAL FEATURES
ESTROGEN-RECEPTOR
ER-ALPHA
SURVIVAL
HPV
3125 Otorhinolaryngology, ophthalmology
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