Ictal and interictal MEG in pediatric patients with tuberous sclerosis and drug resistant epilepsy

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Koptelova , A , Bikmullina , R , Medvedovsky , M , Novikova , S , Golovteev , A , Grinenko , O , Korsakova , M , Kozlova , A , Arkhipova , N , Vorobyev , A , Melikyan , A , Paetau , R , Stroganova , T & Metsähonkala , L 2018 , ' Ictal and interictal MEG in pediatric patients with tuberous sclerosis and drug resistant epilepsy ' , Epilepsy Research , vol. 140 , pp. 162-165 . https://doi.org/10.1016/j.eplepsyres.2017.12.014

Title: Ictal and interictal MEG in pediatric patients with tuberous sclerosis and drug resistant epilepsy
Author: Koptelova, A.; Bikmullina, R.; Medvedovsky, M.; Novikova, S.; Golovteev, A.; Grinenko, O.; Korsakova, M.; Kozlova, A.; Arkhipova, N.; Vorobyev, A.; Melikyan, A.; Paetau, R.; Stroganova, T.; Metsähonkala, L.
Contributor organization: HUS Medical Imaging Center
BioMag Laboratory
University of Helsinki
Kliinisen neurofysiologian yksikkö
Department of Neurosciences
Lastenneurologian yksikkö
Children's Hospital
HUS Children and Adolescents
Date: 2018-02
Language: eng
Number of pages: 4
Belongs to series: Epilepsy Research
ISSN: 0920-1211
DOI: https://doi.org/10.1016/j.eplepsyres.2017.12.014
URI: http://hdl.handle.net/10138/301306
Abstract: Purpose: Drug resistant epilepsy (DRE) is common in patients with tuberous sclerosis (TS). Interictal MEG has been shown as a valuable instrument in the presurgical workup. The goal of our study was to evaluate the role of ictal MEG in epileptogenic tuber selection, especially in patients with multiple irritative zones. Methods: The clinical and MEG data of 23 patients with TS and DRE from two medical/research centers were reviewed. Seven pediatric patients, who had seizures during MEG recording and underwent resection or disconnection surgery, were included into the study. Cortical sources of ictal and interictal epileptiform MEG discharges were compared with epileptogenic zone location in six patients with favorable surgery outcome. Results: In patients who improved substantially after surgery all resected and several other tubers demonstrated epileptiform activity on interictal MEG. Ictal MEG provided crucial information about lobar location of the seizure onset zone (SOZ) in two cases, and in the other four it confirmed the SOZ location derived from the interictal data. In one case, ictal MEG findings were unreliable. In one patient, who did not benefit from surgical treatment, the resected tubers did not overlap with interictal and ictal MEG sources. Conclusion: The combination of interictal and ictal MEG is a valuable tool for identification of the epileptogenic tuber/tubers in presurgical work-up in patients with TS.
Subject: Epilepsy surgery
Tuberous sclerosis
Ictal and interictal MEG
3112 Neurosciences
3124 Neurology and psychiatry
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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