Moving out but keeping in touch : contacts between endoplasmic reticulum and lipid droplets

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http://hdl.handle.net/10138/301334

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Salo , V T & Ikonen , E 2019 , ' Moving out but keeping in touch : contacts between endoplasmic reticulum and lipid droplets ' , Current Opinion in Cell Biology , vol. 57 , pp. 64-70 . https://doi.org/10.1016/j.ceb.2018.11.002

Title: Moving out but keeping in touch : contacts between endoplasmic reticulum and lipid droplets
Author: Salo, Veijo T.; Ikonen, Elina
Contributor: University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
Date: 2019-04
Language: eng
Number of pages: 7
Belongs to series: Current Opinion in Cell Biology
ISSN: 0955-0674
URI: http://hdl.handle.net/10138/301334
Abstract: The formation of neutral lipid filled and phospholipid monolayer engulfed lipid droplets (LDs) from the bilayer of the endoplasmic reticulum (ER) is an active area of investigation. This process harnesses the biophysical properties of the lipids involved and necessitates cooperation of protein machineries in both organelle membranes. Increasing evidence suggests that once formed, LDs keep close contact to the mother organelle and that this may be achieved via several, morphologically distinct and potentially functionally specialized connections. These may help LDs to dynamically respond to changes in lipid metabolic status sensed by the ER. In this review, we will discuss recent progress in understanding how LDs interact with the ER.
Subject: PHOSPHATIDIC-ACID
ER MEMBRANE
SEIPIN
PROMOTES
BIOGENESIS
PROTEINS
RAB18
COMPLEX
LIPODYSTROPHY
TRIGLYCERIDE
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
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