Plasma Heme Scavengers Alpha-l-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies

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Kalapotharakos , G , Murtoniemi , K , Åkerström , B , Hämäläinen , E , Kajantie , E , Räikkönen , K , Villa , P , Laivuori , H & Hansson , S R 2019 , ' Plasma Heme Scavengers Alpha-l-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies ' , Frontiers in Physiology , vol. 10 , 300 . https://doi.org/10.3389/fphys.2019.00300

Title: Plasma Heme Scavengers Alpha-l-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies
Author: Kalapotharakos, Grigorios; Murtoniemi, Katja; Åkerström, Bo; Hämäläinen, Esa; Kajantie, Eero; Räikkönen, Katri; Villa, Pia; Laivuori, Hannele; Hansson, Stefan R.
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Lastentautien yksikkö
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2019-04-04
Language: eng
Number of pages: 7
Belongs to series: Frontiers in Physiology
ISSN: 1664-042X
URI: http://hdl.handle.net/10138/301385
Abstract: Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1 -microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.
Subject: preeclampsia
heme
hemopexin
alpha-1 microglobulin
aspirin
FETAL-HEMOGLOBIN
PREECLAMPSIA
ALPHA(1)-MICROGLOBULIN
DYSFUNCTION
SERUM
1184 Genetics, developmental biology, physiology
3111 Biomedicine
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