A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency

Show simple item record

dc.contributor University of Helsinki, Department of Medicine en
dc.contributor University of Helsinki, Infektiosairauksien yksikkö en
dc.contributor University of Helsinki, Department of Pathology en
dc.contributor University of Helsinki, Department of Clinical Chemistry and Hematology en
dc.contributor University of Helsinki, Children's Hospital en
dc.contributor University of Helsinki, Centre of Excellence in Complex Disease Genetics en
dc.contributor.author Pikkarainen, Sampsa
dc.contributor.author Martelius, Timi
dc.contributor.author Ristimäki, Ari
dc.contributor.author Siitonen, Sanna
dc.contributor.author Seppanen, Mikko R. J.
dc.contributor.author Färkkilä, Martti
dc.date.accessioned 2019-05-02T09:07:02Z
dc.date.available 2019-05-02T09:07:02Z
dc.date.issued 2019-04
dc.identifier.citation Pikkarainen , S , Martelius , T , Ristimäki , A , Siitonen , S , Seppanen , M R J & Färkkilä , M 2019 , ' A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency ' , American Journal of Gastroenterology , vol. 114 , no. 4 , pp. 648-655 . https://doi.org/10.14309/ajg.0000000000000140 en
dc.identifier.issn 0002-9270
dc.identifier.other PURE: 124218746
dc.identifier.other PURE UUID: f1c43db5-23ad-4268-83b7-42c65fb48cb1
dc.identifier.other WOS: 000463404500018
dc.identifier.other ORCID: /0000-0002-0250-8559/work/57044761
dc.identifier.other ORCID: /0000-0001-9733-3650/work/57046315
dc.identifier.uri http://hdl.handle.net/10138/301412
dc.description.abstract OBJECTIVES: Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID. METHODS: Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Data on endoscopies, histology, and laboratory studies were retrieved from patient files. RESULTS: Most common referral indications were diarrhea and/or weight loss (47%-67%). Patients with probable CVID had higher fecal calprotectin and a1-antitrypsin and lower blood vitamin B12 than patients with possible CVID. Gastroscopy and colonoscopy were done to 71 (67%) and 63 (59%) patients with probable CVID, respectively. Endoscopies showed that 15% of them had chronic active gastritis and 17% atrophic gastritis and 3% had gastric adenocarcinoma. A celiac sprue-like condition was found in 7 patients (10%), of whom 3 responded to a gluten-free diet. Colonoscopies demonstrated unspecific colitis (14%), ulcerative colitis (8%), microscopic colitis (10%), and Crohn's disease (2%). Colonic polyps were noted in30% of patients, and3% had lower GI malignancies. Thirty-five patients with CVID had bacterial or parasitic gastroenteritis; chronic norovirus was detected in 4 patients with probable CVID. Patients with GI inflammation had higher levels of fecal calprotectin and blood CD81 T lymphocytes but lower counts of CD191CD271 memory B cells and/or CD191 B cells. Immunophenotype with low B-cell counts was associated with higher fecal calprotectin levels. DISCUSSION: Patients with CVID had a high prevalence of GI manifestations and infections of the GI tract. GI inflammation was associated with a distinct immunophenotype and elevated fecal calprotectin. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof American Journal of Gastroenterology
dc.rights en
dc.subject DEFICIENCY en
dc.subject DISORDERS en
dc.subject PATHOLOGY en
dc.subject 3121 General medicine, internal medicine and other clinical medicine en
dc.subject 3111 Biomedicine en
dc.title A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.14309/ajg.0000000000000140
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl

Files in this item

Total number of downloads: Loading...

Files Size Format View
00000434_201904000_00020.pdf 516.3Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record