Common Inflammation-Related Candidate Gene Variants and Acute Kidney Injury in 2647 Critically Ill Finnish Patients

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Vilander , L M , Vaara , S T , Kaunisto , M A , Pettilä , V , FINNAKI Study Grp , Laru-Sompa , R , Pulkkinen , A , Saarelainen , M , Reilama , M , Tolmunen , S , Rantalainen , U , Miettinen , M , Suvela , M , Pesola , K , Saastamoinen , P , Kauppinen , S , Kaukonen , K-M , Korhonen , A-M , Nisula , S , Vaara , S , Suojaranta-Ylinen , R , Mildh , L , Haapio , M , Nurminen , L , Sutinen , S , Pettilä , L , Laitinen , H , Syrja , H , Henttonen , K , Lappi , E , Boman , H , Varpula , T , Porkka , P , Sivula , M , Rahkonen , M , Tsurkka , A , Nieminen , T , Prittinen , N , Alaspaa , A , Salanto , V , Juntunen , H , Sanisalo , T , Parviainen , I , Uusaro , A , Ruokonen , E , Bendel , S , Rissanen , N , Lång , M , Rahikainen , S , Rissanen , S , Ahonen , M , Halonen , E , Vaskelainen , E , Poukkanen , M , Lintula , E , Suominen , S , Heikkinen , J , Lavander , T , Heinonen , K , Juopperi , A-M , Kaminski , T , Gäddnäs , F , Kuusela , T , Roiko , J , Karlsson , S , Reinikainen , M , Surakka , T , Jyrkönen , H , Eiserbeck , T , Kallinen , J , Lund , V , Tuominen , P , Perkola , P , Tuominen , R , Hietaranta , M , Johansson , S , Hovilehto , S , Kirsi , A , Tiainen , P , Myllärinen , T , Leino , P , Toropainen , A , Kuitunen , A , Leppänen , I , Levoranta , M , Hoppu , S , Sauranen , J , Tenhunen , J , Kukkurainen , A , Kortelainen , S , Varila , S , Inkinen , O , Koivuviita , N , Kotamäki , J , Laine , A , Ala-Kokko , T , Laurila , J J , Sälkiö , S , Koivisto , S-P , Hautamäki , R & Skinnar , M 2019 , ' Common Inflammation-Related Candidate Gene Variants and Acute Kidney Injury in 2647 Critically Ill Finnish Patients ' , Journal of clinical medicine , vol. 8 , no. 3 , 342 . https://doi.org/10.3390/jcm8030342

Title: Common Inflammation-Related Candidate Gene Variants and Acute Kidney Injury in 2647 Critically Ill Finnish Patients
Author: Vilander, Laura M.; Vaara, Suvi T.; Kaunisto, Mari A.; Pettilä, Ville; FINNAKI Study Grp; Laru-Sompa, Raili; Pulkkinen, Anni; Saarelainen, Minna; Reilama, Mikko; Tolmunen, Sinikka; Rantalainen, Ulla; Miettinen, Marja; Suvela, Markku; Pesola, Katrine; Saastamoinen, Pekka; Kauppinen, Sirpa; Kaukonen, Kirsi-Maija; Korhonen, Anna-Maija; Nisula, Sara; Vaara, Suvi; Suojaranta-Ylinen, Raili; Mildh, Leena; Haapio, Mikko; Nurminen, Laura; Sutinen, Sari; Pettilä, Leena; Laitinen, Helinä; Syrja, Heidi; Henttonen, Kirsi; Lappi, Elina; Boman, Hillevi; Varpula, Tero; Porkka, Päivi; Sivula, Mirka; Rahkonen, Mira; Tsurkka, Anne; Nieminen, Taina; Prittinen, Niina; Alaspaa, Ari; Salanto, Ville; Juntunen, Hanna; Sanisalo, Teija; Parviainen, Ilkka; Uusaro, Ari; Ruokonen, Esko; Bendel, Stepani; Rissanen, Niina; Lång, Maarit; Rahikainen, Sari; Rissanen, Saija; Ahonen, Merja; Halonen, Elina; Vaskelainen, Eija; Poukkanen, Meri; Lintula, Esa; Suominen, Sirpa; Heikkinen, Jorma; Lavander, Timo; Heinonen, Kirsi; Juopperi, Anne-Mari; Kaminski, Tadeusz; Gäddnäs, Fiia; Kuusela, Tuija; Roiko, Jane; Karlsson, Sari; Reinikainen, Matti; Surakka, Tero; Jyrkönen, Helena; Eiserbeck, Tanja; Kallinen, Jaana; Lund, Vesa; Tuominen, Päivi; Perkola, Pauliina; Tuominen, Riikka; Hietaranta, Marika; Johansson, Satu; Hovilehto, Seppo; Kirsi, Anne; Tiainen, Pekka; Myllärinen, Tuija; Leino, Pirjo; Toropainen, Anne; Kuitunen, Anne; Leppänen, Ilona; Levoranta, Markus; Hoppu, Sanna; Sauranen, Jukka; Tenhunen, Jyrki; Kukkurainen, Atte; Kortelainen, Samuli; Varila, Simo; Inkinen, Outi; Koivuviita, Niina; Kotamäki, Jutta; Laine, Anu; Ala-Kokko, Tero; Laurila, Jouko J.; Sälkiö, Sinikka; Koivisto, Simo-Pekka; Hautamäki, Raku; Skinnar, Maria
Contributor: University of Helsinki, Anestesiologian yksikkö
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Clinicum
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Anestesiologian yksikkö
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Nefrologian yksikkö
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Anestesiologian yksikkö
University of Helsinki, Clinicum
University of Helsinki, HYKS erva
University of Helsinki, HYKS erva
University of Helsinki, HYKS erva
University of Helsinki, HYKS erva
University of Helsinki, HYKS erva
University of Helsinki, HYKS erva
Date: 2019-03-11
Number of pages: 13
Belongs to series: Journal of clinical medicine
ISSN: 2077-0383
URI: http://hdl.handle.net/10138/301469
Abstract: Acute kidney injury (AKI) is a syndrome with high incidence among the critically ill. Because the clinical variables and currently used biomarkers have failed to predict the individual susceptibility to AKI, candidate gene variants for the trait have been studied. Studies about genetic predisposition to AKI have been mainly underpowered and of moderate quality. We report the association study of 27 genetic variants in a cohort of Finnish critically ill patients, focusing on the replication of associations detected with variants in genes related to inflammation, cell survival, or circulation. In this prospective, observational Finnish Acute Kidney Injury (FINNAKI) study, 2647 patients without chronic kidney disease were genotyped. We defined AKI according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria. We compared severe AKI (Stages 2 and 3, n = 625) to controls (Stage 0, n = 1582). For genotyping we used iPLEX(TM) Assay (Agena Bioscience). We performed the association analyses with PLINK software, using an additive genetic model in logistic regression. Despite the numerous, although contradictory, studies about association between polymorphisms rs1800629 in TNFA and rs1800896 in IL10 and AKI, we found no association (odds ratios 1.06 (95% CI 0.89-1.28, p = 0.51) and 0.92 (95% CI 0.80-1.05, p = 0.20), respectively). Adjusting for confounders did not change the results. To conclude, we could not confirm the associations reported in previous studies in a cohort of critically ill patients.
Subject: acute kidney injury
genetic variation
human genetics
NECROSIS-FACTOR-ALPHA
ENDOTHELIAL GROWTH-FACTOR
GENOME-WIDE ASSOCIATION
PROMOTER POLYMORPHISM
ADVERSE OUTCOMES
PLASMA-LEVELS
RISK-FACTORS
SEPSIS
MORTALITY
INTERLEUKIN-10
3121 Internal medicine
1184 Genetics, developmental biology, physiology
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