Risk of lung cancer and physical activity by smoking status and body mass index, the Norwegian Women and Cancer Study

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Borch , K B , Weiderpass , E , Braaten , T , Hansen , M S & Licaj , I 2019 , ' Risk of lung cancer and physical activity by smoking status and body mass index, the Norwegian Women and Cancer Study ' , European Journal of Epidemiology , vol. 34 , no. 5 , pp. 489-498 . https://doi.org/10.1007/s10654-018-0446-0

Title: Risk of lung cancer and physical activity by smoking status and body mass index, the Norwegian Women and Cancer Study
Author: Borch, Kristin Benjaminsen; Weiderpass, Elisabete; Braaten, Tonje; Hansen, Merethe Selnes; Licaj, Idlir
Contributor: University of Helsinki, Department of Medical and Clinical Genetics
Date: 2019
Language: eng
Number of pages: 10
Belongs to series: European Journal of Epidemiology
ISSN: 0393-2990
URI: http://hdl.handle.net/10138/301520
Abstract: We aimed to investigate physical activity (PA) and risk of different histological subtypes of lung cancer according to smoking status and body mass index using repeated measurements in a large cohort of women in Norway. The study sample for the multiple imputation analyses consisted of 86,499 and for the complete-case analysis 80,802 women. Repeated measurements of PA level, smoking habits, weight, and height were available for 54,691 women (63.2%), who were included in repeated measurement analyses combined with multiple imputation to address attrition. Cox proportional hazards regression models were used to calculate hazard ratios with 95% confidence intervals. During a median follow-up of 12.9years, 866 cases of primary lung cancer were identified. We found an inverse association between PA and lung cancer overall. The results were consistent from multiple imputed data analysis to complete-case analysis of PA and possible confounders. We observed a similar trend for adenocarcinoma, but not for squamous cell or small cell carcinomas. Our findings suggest a more pronounced association between lung cancer overall and PA levels in current and former smokers, and in normal-weight and overweight participants with increasing PA levels. The potential of a modifiable lifestyle factor as PA to reduce the risk of lung cancer independently of smoking status is important in public health.
Subject: Lung cancer
Physical activity
Smoking
Prospective study
Women
LEISURE-TIME
BREAST-CANCER
OLDER WOMEN
FOLLOW-UP
COHORT
MORTALITY
MEN
CONSUMPTION
VALIDITY
HABITS
3142 Public health care science, environmental and occupational health
3122 Cancers
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