Brain mechanisms underlying cue-based memorizing during free viewing of movie Memento

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http://hdl.handle.net/10138/301556

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Kauttonen , J , Hlushchuk , Y , Jaaskelainen , I P & Tikka , P 2018 , ' Brain mechanisms underlying cue-based memorizing during free viewing of movie Memento ' , NeuroImage , vol. 172 , pp. 313-325 . https://doi.org/10.1016/j.neuroimage.2018.01.068

Title: Brain mechanisms underlying cue-based memorizing during free viewing of movie Memento
Author: Kauttonen, Janne; Hlushchuk, Yevhen; Jaaskelainen, Iiro P.; Tikka, Pia
Contributor: University of Helsinki, Faculty of Medicine
Date: 2018-05-15
Language: eng
Number of pages: 13
Belongs to series: NeuroImage
ISSN: 1053-8119
URI: http://hdl.handle.net/10138/301556
Abstract: How does the human brain recall and connect relevant memories with unfolding events? To study this, we presented 25 healthy subjects, during functional magnetic resonance imaging, the movie 'Memento' (director C. Nolan). In this movie, scenes are presented in chronologically reverse order with certain scenes briefly overlapping previously presented scenes. Such overlapping "key-frames" serve as effective memory cues for the viewers, prompting recall of relevant memories of the previously seen scene and connecting them with the concurrent scene. We hypothesized that these repeating key-frames serve as immediate recall cues and would facilitate reconstruction of the story piece-by-piece. The chronological version of Memento, shown in a separate experiment for another group of subjects, served as a control condition. Using multivariate event-related pattern analysis method and representational similarity analysis, focal fingerprint patterns of hemodynamic activity were found to emerge during presentation of key-frame scenes. This effect was present in higher-order cortical network with regions including precuneus, angular gyrus, cingulate gyrus, as well as lateral, superior, and middle frontal gyri within frontal poles. This network was right hemispheric dominant. These distributed patterns of brain activity appear to underlie ability to recall relevant memories and connect them with ongoing events, i.e., "what goes with what" in a complex story. Given the real-life likeness of cinematic experience, these results provide new insight into how the human brain recalls, given proper cues, relevant memories to facilitate understanding and prediction of everyday life events.
Subject: fMRI
Naturalistic stimulus
Neurocinematics
Pattern analysis
Cued-recall
Schema
EPISODIC MEMORY RETRIEVAL
COMMON NEURAL CODE
VOXEL PATTERN-ANALYSIS
DEFAULT-MODE NETWORK
PREFRONTAL CORTEX
FUNCTIONAL CONNECTIVITY
RECOLLECTION NETWORK
CORTICAL ACTIVITY
CINGULATE CORTEX
RIGHT-HEMISPHERE
3112 Neurosciences
3126 Surgery, anesthesiology, intensive care, radiology
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