Lower heart rate is associated with good one-year outcome in post-resuscitation patients

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FINNRESUSCI Study Grp , Oksanen , T , Tiainen , M , Vaahersalo , J , Bendel , S , Varpula , T , Skrifvars , M , Pettilä , V & Wilkman , E 2018 , ' Lower heart rate is associated with good one-year outcome in post-resuscitation patients ' , Resuscitation , vol. 128 , pp. 112-118 . https://doi.org/10.1016/j.resuscitation.2018.05.001

Title: Lower heart rate is associated with good one-year outcome in post-resuscitation patients
Author: FINNRESUSCI Study Grp; Oksanen, Tuomas; Tiainen, Marjaana; Vaahersalo, Jukka; Bendel, Stepani; Varpula, Tero; Skrifvars, Markus; Pettilä, Ville; Wilkman, Erika
Contributor organization: Anestesiologian yksikkö
Department of Diagnostics and Therapeutics
University of Helsinki
HUS Perioperative, Intensive Care and Pain Medicine
Neurologian yksikkö
Department of Neurosciences
HUS Neurocenter
Date: 2018-07
Language: eng
Number of pages: 7
Belongs to series: Resuscitation
ISSN: 0300-9572
DOI: https://doi.org/10.1016/j.resuscitation.2018.05.001
URI: http://hdl.handle.net/10138/301649
Abstract: Background: Optimal hemodynamic goals in post-resuscitation patients are not clear. Previous studies have reported an association between lower heart rate and good outcome in patients receiving targeted temperature management (TTM) after out-of-hospital cardiac arrest. Methods: We analyzed heart rate (HR) and outcome data of 504 post-resuscitation patients from the prospectively collected database of the FINNRESUSCI study. One-year neurologic outcome was dichotomized by the Cerebral Performance Category (CPC) to good (1-2) or poor (3-5). Results: Of 504 patients, 40.1% (202/504) had good and 59.9% (302/504) had poor one-year neurologic outcome. Patients with good outcome had lower time-weighted mean HR during the first 48 h in the ICU (69.2 bpm [59.2-75.1] vs. 76.6 bpm [65.72-89.6], p <0.001) and the first 72 h in the ICU (71.2 bpm [65.0-79.0] vs. 77.1 bpm [69.1-90.1, p <0.001]). The percentage of HR registrations below HR threshold values (60, 80 and 100 bpm) were higher for patients with good neurologic outcome, p <0.001 for all. Lower time-weighted HR for 0-48 h and 0-72 h, and a higher percentage of HR recordings below threshold values were independently associated with good neurological one-year outcome (p <0.05 for all). When TTM and non-TTM patients were analyzed separately, HR parameters were independently associated with one-year neurologic outcome only in non-TTM patients. Conclusion: Lower heart rate was independently associated with good neurologic outcome. Whether HR in post-resuscitation patients is a prognostic indicator or an important variable to be targeted by treatment, needs to be assessed in future prospective controlled clinical trials.
Subject: Postresuscitation
Heart rate
Therapeutic temperature management
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

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