MAPK/ERK Signaling in Regulation of Renal Differentiation

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Kurtzeborn , K , Kwon , H N & Kuure , S 2019 , ' MAPK/ERK Signaling in Regulation of Renal Differentiation ' , International Journal of Molecular Sciences , vol. 20 , no. 7 , 1779 . https://doi.org/10.3390/ijms20071779

Title: MAPK/ERK Signaling in Regulation of Renal Differentiation
Author: Kurtzeborn, Kristen; Kwon, Hyuk Nam; Kuure, Satu
Contributor: University of Helsinki, Helsinki Institute of Life Science HiLIFE, Joint Activities
University of Helsinki, Kidney development
University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
Date: 2019-04
Language: eng
Number of pages: 21
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
URI: http://hdl.handle.net/10138/301873
Abstract: Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the major cause of end-stage renal disease and chronic kidney diseases in children, but its genetic causes remain largely unresolved. Here we discuss advances in the understanding of how mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) activity contributes to the regulation of ureteric bud branching morphogenesis, which dictates the final size, shape, and nephron number of the kidney. Recent studies also demonstrate that the MAPK/ERK pathway is directly involved in nephrogenesis, regulating both the maintenance and differentiation of the nephrogenic mesenchyme. Interestingly, aberrant MAPK/ERK signaling is linked to many cancers, and recent studies suggest it also plays a role in the most common pediatric renal cancer, Wilms' tumor.
Subject: extracellular signal-regulated kinase
MAPK
ERK signaling
intracellular signaling
kidney development
ureteric bud branching morphogenesis
nephrogenesis
progenitor cells
self-renewal
differentiation
ACTIVATED PROTEIN-KINASE
NEPHRON PROGENITOR CELLS
URETERAL BUD OUTGROWTH
P38 MAP KINASE
BRANCHING MORPHOGENESIS
MICE LACKING
KIDNEY DEVELOPMENT
NEUROTROPHIC FACTOR
MAMMALIAN KIDNEY
GENE-EXPRESSION
1182 Biochemistry, cell and molecular biology
116 Chemical sciences
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