Short-term escitalopram treatment normalizes aberrant self-referential processing in major depressive disorder

Show simple item record

dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, University of Helsinki en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Department of Psychiatry en
dc.contributor.author Komulainen, Emma
dc.contributor.author Heikkilä, Roope
dc.contributor.author Nummenmaa, Lauri
dc.contributor.author Raij, Tuukka T.
dc.contributor.author Harmer, Catherine J.
dc.contributor.author Isometsä, Erkki
dc.contributor.author Ekelund, Jesper
dc.date.accessioned 2019-05-20T21:40:24Z
dc.date.available 2021-04-20T21:45:51Z
dc.date.issued 2018-08-15
dc.identifier.citation Komulainen , E , Heikkilä , R , Nummenmaa , L , Raij , T T , Harmer , C J , Isometsä , E & Ekelund , J 2018 , ' Short-term escitalopram treatment normalizes aberrant self-referential processing in major depressive disorder ' , Journal of Affective Disorders , vol. 236 , pp. 222-229 . https://doi.org/10.1016/j.jad.2018.04.096 en
dc.identifier.issn 0165-0327
dc.identifier.other PURE: 107824503
dc.identifier.other PURE UUID: 872c9902-3de6-48ee-8da2-020945eb26c0
dc.identifier.other WOS: 000433130600032
dc.identifier.other Scopus: 85046659522
dc.identifier.uri http://hdl.handle.net/10138/301887
dc.description.abstract Background: Increased self-focus and negative self-concept play an important role in depression. Antidepressants influence self-referential processing in healthy volunteers, but their function in self-processing of depressed patients remains unknown. Methods: Thirty-two depressed patients were randomly allocated to receive either escitalopram 10 mg or placebo for one week. After one week, neural responses to positive and negative self-referential adjectives and neutral control stimuli were assessed with functional magnetic resonance imaging. A group of matched healthy volunteers served as a control group. Results: Escitalopram decreased responses of medial fronto-parietal regions to self-referential words relative to non-emotional control stimuli, driven by increased responses to the control condition. Escitalopram also increased responses in the pre-defined region of the medial prefrontal cortex (MPFC) and the anterior cingulate cortex (ACC) to positive relative to negative words. Importantly, the changes in neural responses occurred before any effect on depressive symptoms, implying a direct effect of escitalopram. Furthermore, the placebo group had decreased responses of the MPFC and the ACC to positive self-referential processing relative to the matched healthy controls. However, neural responses of the escitalopram group and the healthy unmedicated controls were similar. Limitations: Differences between the groups in self-reported depression symptoms and personality traits may have influenced the results. Conclusion: One-week treatment with escitalopram normalized aberrant self-referential processing in depressed patients, shifting the focus from the self to the external environment and potentiating positive self-referential processing. This may be an important factor in mechanism of action of antidepressants. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Journal of Affective Disorders
dc.rights en
dc.subject Depression en
dc.subject Antidepressant en
dc.subject Escitalopram en
dc.subject fMRI en
dc.subject Emotion en
dc.subject Self-referential processing en
dc.subject DEFAULT-MODE NETWORK en
dc.subject MEDIAL PREFRONTAL CORTEX en
dc.subject HEALTHY-VOLUNTEERS en
dc.subject FUNCTIONAL CONNECTIVITY en
dc.subject BRAIN en
dc.subject METAANALYSIS en
dc.subject DISEASE en
dc.subject FMRI en
dc.subject MRI en
dc.subject RECOGNITION en
dc.subject 3112 Neurosciences en
dc.subject 3124 Neurology and psychiatry en
dc.title Short-term escitalopram treatment normalizes aberrant self-referential processing in major depressive disorder en
dc.type Article
dc.description.version Peer reviewed
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1016/j.jad.2018.04.096
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/acceptedVersion
dc.type.uri info:eu-repo/semantics/publishedVersion
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl

Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0165032717322814_main.pdf 1.047Mb PDF View/Open
1_s2.0_S0165032717322814_main.pdf 1.027Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record