Cartography of rhodopsin-like G protein-coupled receptors across vertebrate genomes

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Rinne , M , Tanoli , Z-U-R , Khan , A & Xhaard , H 2019 , ' Cartography of rhodopsin-like G protein-coupled receptors across vertebrate genomes ' , Scientific Reports , vol. 9 , 7058 . https://doi.org/10.1038/s41598-018-33120-8

Title: Cartography of rhodopsin-like G protein-coupled receptors across vertebrate genomes
Author: Rinne, Maiju; Tanoli, Zia-Ur-Rehman; Khan, Asifullah; Xhaard, Henri
Contributor organization: Division of Pharmaceutical Chemistry and Technology
Drug Research Program
Pharmaceutical Design and Discovery group
Henri Xhaard / Principal Investigator
Date: 2019-05-07
Language: eng
Number of pages: 16
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-018-33120-8
URI: http://hdl.handle.net/10138/302032
Abstract: We conduct a cartography of rhodopsin-like non-olfactory G protein-coupled receptors in the Ensembl database. The most recent genomic data (releases 90-92, 90 vertebrate genomes) are analyzed through the online interface and receptors mapped on phylogenetic guide trees that were constructed based on a set of similar to 14.000 amino acid sequences. This snapshot of genomic data suggest vertebrate genomes to harbour 142 clades of GPCRs without human orthologues. Among those, 69 have not to our knowledge been mentioned or studied previously in the literature, of which 28 are distant from existing receptors and likely new orphans. These newly identified receptors are candidates for more focused evolutionary studies such as chromosomal mapping as well for in-depth pharmacological characterization. Interestingly, we also show that 37 of the 72 human orphan (or recently deorphanized) receptors included in this study cluster into nineteen closely related groups, which implies that there are less ligands to be identified than previously anticipated. Altogether, this work has significant implications when discussing nomenclature issues for GPCRs.
Subject: MOLECULAR EVOLUTION
EXPRESSION ANALYSIS
HORMONE-RECEPTORS
GENE DUPLICATION
XENOPUS-LAEVIS
ZEBRAFISH
CLONING
IDENTIFICATION
FAMILY
REPERTOIRE
1184 Genetics, developmental biology, physiology
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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