Fibroblast Growth Factor 21, Adiponectin, and Irisin as Markers of Unfavorable Metabolic Features in 12-Year-Old Children

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Seppa , S , Tenhola , S & Voutilainen , R 2019 , ' Fibroblast Growth Factor 21, Adiponectin, and Irisin as Markers of Unfavorable Metabolic Features in 12-Year-Old Children ' , Journal of the Endocrine Society , vol. 3 , no. 4 , pp. 825-837 . https://doi.org/10.1210/js.2018-00399

Title: Fibroblast Growth Factor 21, Adiponectin, and Irisin as Markers of Unfavorable Metabolic Features in 12-Year-Old Children
Author: Seppa, Satu; Tenhola, Sirpa; Voutilainen, Raimo
Other contributor: University of Helsinki, HYKS erva
University of Helsinki, Kuopio University Hospital (KYS)
Date: 2019-04
Language: eng
Number of pages: 13
Belongs to series: Journal of the Endocrine Society
ISSN: 2472-1972
DOI: https://doi.org/10.1210/js.2018-00399
URI: http://hdl.handle.net/10138/302294
Abstract: Context: Among cytokines, fibroblast growth factor 21 (FGF21), adiponectin (Adn), and irisin have been considered potential biomarkers for insulin sensitivity (IS). Objective: We evaluated whether serum FGF21, Adn, and irisin associate with markers of IS and serum lipids in 12-year-old children. Design, Participants, and Main Outcome Measures: This cohort study included 192 12-year-old children (109 girls). Seventy-eight of them had been born appropriate for gestational age (AGA), 70 small for gestational age (SGA), and 44 from preeclamptic pregnancies (PREs) as AGA. Fasting serum FGF21, Adn, irisin, lipids, inflammatory markers, and IS markers were measured. Quantitative insulin sensitivity check index (QUICKI) was calculated. Results: The means of serum FGF21, high molecular weight (HMW) Adn, and irisin did not differ between the sexes or between the SGA, AGA, and PRE children. In the whole study population, FGF21 associated positively with irisin and uric acid and negatively with leptin and high-density lipoprotein cholesterol (HDL-C). HMW Adn associated positively with total Adn, HDL-C, leptin, and SHBG. Apart from FGF21, irisin associated positively with insulin, high-sensitivity C-reactive protein, y-glutamyltransferase, and triglycerides, and negatively with QUICKI, SHBG, and IGF binding protein-1. In multivariate regression analyses, irisin predicted lower IS and HMW Adn predicted higher HDL-C body mass index-independently, whereas FGF21 had no independent contribution to IS or lipid variables. Conclusion: In 12-year-old children, serum irisin was associated with markers reflecting reduced IS. HMW Adn predicted HDL-C, whereas FGF21 did not contribute to IS or lipid parameters in multivariate regression analyses. Copyright (C) 2019 Endocrine Society
Subject: adipocytokines
myokines
cardiovascular disease risk
insulin resistance
ASSESSING INSULIN SENSITIVITY
AMBULATORY BLOOD-PRESSURE
HIGH-MOLECULAR-WEIGHT
CIRCULATING IRISIN
CARDIOVASCULAR RISK
RESISTANCE
BORN
ASSOCIATION
OBESITY
ADIPOKINES
3121 General medicine, internal medicine and other clinical medicine
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