Fibroblast Growth Factor 21, Adiponectin, and Irisin as Markers of Unfavorable Metabolic Features in 12-Year-Old Children

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dc.contributor.author Seppa, Satu
dc.contributor.author Tenhola, Sirpa
dc.contributor.author Voutilainen, Raimo
dc.date.accessioned 2019-05-29T09:31:01Z
dc.date.available 2019-05-29T09:31:01Z
dc.date.issued 2019-04
dc.identifier.citation Seppa , S , Tenhola , S & Voutilainen , R 2019 , ' Fibroblast Growth Factor 21, Adiponectin, and Irisin as Markers of Unfavorable Metabolic Features in 12-Year-Old Children ' , Journal of the Endocrine Society , vol. 3 , no. 4 , pp. 825-837 . https://doi.org/10.1210/js.2018-00399
dc.identifier.other PURE: 124912895
dc.identifier.other PURE UUID: ee68f942-6f4e-4eba-a621-ee20637c884a
dc.identifier.other WOS: 000463993200014
dc.identifier.uri http://hdl.handle.net/10138/302294
dc.description.abstract Context: Among cytokines, fibroblast growth factor 21 (FGF21), adiponectin (Adn), and irisin have been considered potential biomarkers for insulin sensitivity (IS). Objective: We evaluated whether serum FGF21, Adn, and irisin associate with markers of IS and serum lipids in 12-year-old children. Design, Participants, and Main Outcome Measures: This cohort study included 192 12-year-old children (109 girls). Seventy-eight of them had been born appropriate for gestational age (AGA), 70 small for gestational age (SGA), and 44 from preeclamptic pregnancies (PREs) as AGA. Fasting serum FGF21, Adn, irisin, lipids, inflammatory markers, and IS markers were measured. Quantitative insulin sensitivity check index (QUICKI) was calculated. Results: The means of serum FGF21, high molecular weight (HMW) Adn, and irisin did not differ between the sexes or between the SGA, AGA, and PRE children. In the whole study population, FGF21 associated positively with irisin and uric acid and negatively with leptin and high-density lipoprotein cholesterol (HDL-C). HMW Adn associated positively with total Adn, HDL-C, leptin, and SHBG. Apart from FGF21, irisin associated positively with insulin, high-sensitivity C-reactive protein, y-glutamyltransferase, and triglycerides, and negatively with QUICKI, SHBG, and IGF binding protein-1. In multivariate regression analyses, irisin predicted lower IS and HMW Adn predicted higher HDL-C body mass index-independently, whereas FGF21 had no independent contribution to IS or lipid variables. Conclusion: In 12-year-old children, serum irisin was associated with markers reflecting reduced IS. HMW Adn predicted HDL-C, whereas FGF21 did not contribute to IS or lipid parameters in multivariate regression analyses. Copyright (C) 2019 Endocrine Society en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Journal of the Endocrine Society
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject adipocytokines
dc.subject myokines
dc.subject cardiovascular disease risk
dc.subject insulin resistance
dc.subject ASSESSING INSULIN SENSITIVITY
dc.subject AMBULATORY BLOOD-PRESSURE
dc.subject HIGH-MOLECULAR-WEIGHT
dc.subject CIRCULATING IRISIN
dc.subject CARDIOVASCULAR RISK
dc.subject RESISTANCE
dc.subject BORN
dc.subject ASSOCIATION
dc.subject OBESITY
dc.subject ADIPOKINES
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Fibroblast Growth Factor 21, Adiponectin, and Irisin as Markers of Unfavorable Metabolic Features in 12-Year-Old Children en
dc.type Article
dc.contributor.organization HYKS erva
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1210/js.2018-00399
dc.relation.issn 2472-1972
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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