Utility of Different Blood Pressure Measurement Components in Childhood to Predict Adult Carotid Intima-Media Thickness : The i3C Consortium Study

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Koskinen , J , Juonala , M , Dwyer , T , Venn , A , Petkeviciene , J , Ceponiene , I , Bazzano , L , Chen , W , Sabin , M A , Burns , T L , Viikari , J S A , Woo , J G , Urbina , E M , Prineas , R , Hutri-Kähönen , N , Sinaiko , A , Jacobs , D R , Steinberger , J , Daniels , S , Raitakari , O & Magnussen , C G 2019 , ' Utility of Different Blood Pressure Measurement Components in Childhood to Predict Adult Carotid Intima-Media Thickness : The i3C Consortium Study ' , Hypertension , vol. 73 , no. 2 , pp. 335-341 . https://doi.org/10.1161/HYPERTENSIONAHA.118.12225

Title: Utility of Different Blood Pressure Measurement Components in Childhood to Predict Adult Carotid Intima-Media Thickness : The i3C Consortium Study
Author: Koskinen, Juha; Juonala, Markus; Dwyer, Terence; Venn, Alison; Petkeviciene, Janina; Ceponiene, Indre; Bazzano, Lydia; Chen, Wei; Sabin, Matthew A.; Burns, Trudy L.; Viikari, Jorma S. A.; Woo, Jessica G.; Urbina, Elaine M.; Prineas, Ronald; Hutri-Kähönen, Nina; Sinaiko, Alan; Jacobs, David R.; Steinberger, Julia; Daniels, Stephen; Raitakari, Olli; Magnussen, Costan G.
Contributor: University of Helsinki, HYKS erva
Date: 2019-02
Language: eng
Number of pages: 7
Belongs to series: Hypertension
ISSN: 0194-911X
URI: http://hdl.handle.net/10138/302295
Abstract: Childhood blood pressure (BP) levels predict adult subclinical atherosclerosis. However, the best childhood BP component for prediction has not been determined. This study comprised 5925 participants aged 3 to 18 years from 6 cohorts who were followed into adulthood (mean follow-up 25.8 +/- 6.2 years). Childhood BP was measured by using a standard mercury sphygmomanometer in all cohorts. Study-specific carotid intima-media thickness 90th percentile was used to define subclinical atherosclerosis. Per SD change in the predictor, childhood systolic BP (SBP; age- and sex-adjusted odds ratio [95% CI], 1.24 [1.13-1.37]), mean arterial pressure (1.10 [1.07-1.13]), and pulse pressure (1.15 [1.05-1.27]) were associated with increased adulthood intima-media thickness. In age- and sex-adjusted analyses, area under the receiver operating characteristic curves for SBP (C value [95% CI], 0.677 [0.657-0.704]) showed significantly improved prediction compared with diastolic BP (0.669 [0.646-0.693], P=0.006) or mean arterial pressure (0.674 [0.653-0.699], P=0.01). Pulse pressure provided a C value that was not different from SBP (0.676 [0.653-0.699], P=0.16). Combining different BP components did not improve prediction over SBP measurement alone. Based on the associations with adult carotid intima-media thickness, cut points for elevated SBP were 105 mmHg for 3- to 6-year-old boys, 108 mmHg for 3- to 6-year-old girls, 108 mmHg for 7- to 12-year-old boys, 106 mmHg for 7- to 12-year-old girls, 123 mmHg for 13- to 18-year-old boys, and 115 mmHg for 13- to 18-year-old girls. Our analyses suggest that several childhood BP measurement components are related to adulthood carotid intima-media thickness. Of these, SBP provided the best predictive ability.
Subject: arterial pressure
atherosclerosis
blood pressure
epidemiology
pediatrics
CARDIOVASCULAR RISK-FACTORS
INSULIN-RESISTANCE
SUBCLINICAL ATHEROSCLEROSIS
YOUNG FINNS
ASSOCIATIONS
DETERMINANTS
TRACKING
CHILDREN
AGE
ADOLESCENCE
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
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