Validating 10-joint juvenile arthritis disease activity score cut-offs for disease activity levels in non-systemic juvenile idiopathic arthritis

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Backström , M , Tynjälä , P , Aalto , K , Grönlund , M-M , Ylijoki , H , Putto-Laurila , A , Kärki , J , Keskitalo , P , Sard , S , Pohjankoski , H , Hietanen , M , Witter , S , Lehto , H , Löyttyniemi , E & Vähäsalo , P 2019 , ' Validating 10-joint juvenile arthritis disease activity score cut-offs for disease activity levels in non-systemic juvenile idiopathic arthritis ' , RMD open , vol. 5 , no. 1 , 000888 . https://doi.org/10.1136/rmdopen-2018-000888

Title: Validating 10-joint juvenile arthritis disease activity score cut-offs for disease activity levels in non-systemic juvenile idiopathic arthritis
Author: Backström, Maria; Tynjälä, Pirjo; Aalto, Kristiina; Grönlund, Minna-Maija; Ylijoki, Heikki; Putto-Laurila, Anne; Kärki, Johanna; Keskitalo, Paula; Sard, Sirja; Pohjankoski, Heini; Hietanen, Maiju; Witter, Silke; Lehto, Helena; Löyttyniemi, Eliisa; Vähäsalo, Paula
Contributor: University of Helsinki, HYKS erva
University of Helsinki, Children's Hospital
University of Helsinki, HYKS erva
University of Helsinki, HYKS erva
University of Helsinki, HYKS erva
Date: 2019-02
Language: eng
Number of pages: 9
Belongs to series: RMD open
ISSN: 2056-5933
URI: http://hdl.handle.net/10138/302298
Abstract: Objectives To validate cut-offs of the Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) and to compare them with other patient cohorts. Methods In a national multicentre study, cross-sectional data on recent visits of 337 non-systemic patients with juvenile idiopathic arthritis (JIA) were collected from nine paediatric outpatient units. The cut-offs were tested with receiver operating characteristic curve-based methods, and too high, too low and correct classification rates (CCRs) were calculated. Results Our earlier presented JADAS10 cut-offs seemed feasible based on the CCRs, but the cut-off values between low disease activity (LDA) and moderate disease activity (MDA) were adjusted. When JADAS10 cut-offs for clinically inactive disease (CID) were increased to 1.5 for patients with oligoarticular disease and 2.7 for patients with polyarticular disease, as recently suggested in a large multinational register study, altogether 11 patients classified as CID by the cut-off had one active joint. We suggest JADAS10 cut-off values for oligoarticular/polyarticular disease to be in CID: 0.0-0.5/0.0-0.7, LDA: 0.6-3.8/0.8-5.1 and MDA: >3.8/5.1. Suitable cJADAS10 cut-offs are the same as JADAS10 cut-offs in oligoarticular disease. In polyarticular disease, cJADAS10 cut-offs are 0-0.7 for CID, 0.8-5.0 for LDA and > 5.0 for MDA. Conclusion I nternational consensus on JADAS cutoff values is needed, and such a cut-off for CID should preferably exclude patients with active joints in the CID group.
Subject: DEFINING CRITERIA
INACTIVE DISEASE
CHILDREN
THERAPY
PREDICTS
STATE
3121 General medicine, internal medicine and other clinical medicine
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