Appendiceal neoplasm risk associated with complicated acute appendicitisa population based study

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Lietzen , E , GrÖnroos , J M , Mecklin , J-P , Leppäniemi , A , Nordström , P , Rautio , T , Rantanen , T , Sand , J , Paajanen , H , Kaljonen , A & Salminen , P 2019 , ' Appendiceal neoplasm risk associated with complicated acute appendicitisa population based study ' , International Journal of Colorectal Disease , vol. 34 , no. 1 , pp. 39-46 .

Title: Appendiceal neoplasm risk associated with complicated acute appendicitisa population based study
Author: Lietzen, Elina; GrÖnroos, Juha M.; Mecklin, Jukka-Pekka; Leppäniemi, Ari; Nordström, Pia; Rautio, Tero; Rantanen, Tuomo; Sand, Juhani; Paajanen, Hannu; Kaljonen, Anne; Salminen, Paulina
Contributor organization: II kirurgian klinikka
University of Helsinki
HUS Abdominal Center
HYKS erva
Päijät-Häme Welfare Consortium
Date: 2019-01
Language: eng
Number of pages: 8
Belongs to series: International Journal of Colorectal Disease
ISSN: 0179-1958
Abstract: PurposeAppendiceal tumors are rare, but high neoplasm rates have been reported at interval appendectomy after periappendicular abscess. Non-operative management of uncomplicated acute appendicitis has shown promising results. The data on appendiceal tumor incidence and presentation among acute appendicitis patients is limited, especially in patient cohorts differentiating between uncomplicated and complicated acute appendicitis. Objective was to assess appendiceal tumor incidence and tumor association to appendicitis in patients with uncomplicated and complicated acute appendicitis.MethodsThis nationwide population-based registry study was conducted from 2007 to 2013. The Finnish Cancer Registry and the National Institute for Health Registry were used to combine data on all appendiceal tumors and acute appendicitis diagnosis with medical reports evaluated at eight study hospitals.ResultsAltogether, 840 appendiceal tumors were identified, and out of these, 504 patient reports were reviewed, including 472 patients in this study. Tumor was diagnosed at appendectomy for suspected acute appendicitis in 276 patients (58%). In the whole study, histologically acute appendicitis and tumor were both present in 53% (n=250), and out of these, 41% (n=102) were complicated and 59% (n=148) uncomplicated acute appendicitis. The associated tumor risk was significantly higher in complicated acute appendicitis compared with uncomplicated cases (3.24% vs. 0.87%, p
Subject: Acute appendicitis
Uncomplicated acute appendicitis
Complicated acute appendicitis
Non-operative treatment
Appendiceal neoplasm
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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