Serologically diagnosed acute human bocavirus 1 infection in childhood community-acquired pneumonia

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Nascimento-Carvalho , A C , Vilas-Boas , A-L , Fontoura , M-S H , Xu , M , Vuorinen , T , Söderlund-Venermo , M , Ruuskanen , O , Nascimento-Carvalho , C M & PNEUMOPAC-Efficacy Study Grp 2018 , ' Serologically diagnosed acute human bocavirus 1 infection in childhood community-acquired pneumonia ' , Pediatric Pulmonology , vol. 53 , no. 1 , pp. 88-94 . https://doi.org/10.1002/ppul.23891

Title: Serologically diagnosed acute human bocavirus 1 infection in childhood community-acquired pneumonia
Author: Nascimento-Carvalho, Amanda C.; Vilas-Boas, Ana-Luisa; Fontoura, Maria-Socorro H.; Xu, Man; Vuorinen, Tytti; Söderlund-Venermo, Maria; Ruuskanen, Olli; Nascimento-Carvalho, Cristiana M.; PNEUMOPAC-Efficacy Study Grp
Contributor: University of Helsinki, Doctoral Programme in Biomedicine
University of Helsinki, Medicum
Date: 2018-01
Language: eng
Number of pages: 7
Belongs to series: Pediatric Pulmonology
ISSN: 8755-6863
URI: http://hdl.handle.net/10138/302388
Abstract: AimTo assess the role of human bocavirus 1 (HBoV1) as a causative agent of non-severe community-acquired pneumonia (CAP) in children. MethodsPatients aged 2-59 months with non-severe CAP (respiratory complaints and radiographic pulmonary infiltrate/consolidation) attending a University Hospital in Salvador, Brazil were enrolled in a prospective cohort. From 820 recruited children in a clinical trial ( NCT01200706), nasopharyngeal aspirate (NPA), and acute and convalescent serum samples were obtained from 759 (92.6%) patients. NPAs were tested for 16 respiratory viruses by PCR. Acute HBoV1 infection was confirmed by measuring specific IgM and IgG responses in paired serum samples. ResultsRespiratory viruses were detected in 693 (91.3%; 95%CI: 89.1-93.2) CAP cases by PCR. HBoV1-DNA was detected in 159 (20.9%; 95%CI: 18.2-24.0) cases. Of these 159 PCR positive cases, acute HBoV1 infection was confirmed serologically in 38 cases (23.9%; 95%CI: 17.8-31.0). Overall, acute HBoV1 infection was confirmed in 5.0% (38/759) of non-severe CAP patients. HBoV1 was detected in 151 cases with at least one other virus making 31.7% of all multiple virus (n=477) detections. Among all 759 cases, 216 had one respiratory virus detected, and sole HBoV1 was detected in only 8 (3.7%). Acute HBoV1 infection was serologically diagnosed in 34 (22.5%) HBoV1-DNA-positive cases with another virus, compared to 4 (50.0%) cases with sole virus detection (p=0.09). ConclusionHBoV1 was detected by PCR in one fifth of the children with non-severe CAP and acute HBoV1 infection was serologically confirmed in one quarter of these cases.
Subject: 3123 Gynaecology and paediatrics
3111 Biomedicine
acute respiratory infection
children
lower respiratory tract infection
respiratory virus
viral infection
RESPIRATORY VIRUS-INFECTIONS
CHILDREN
SEVERITY
INFANTS
DISEASE
SAMPLES
BURDEN
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