Fasting blood glucose, glycaemic control and prostate cancer risk in the Finnish Randomized Study of Screening for Prostate Cancer

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http://hdl.handle.net/10138/302397

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Murtola , T J , Vihervuori , V J Y , Lahtela , J , Talala , K , Taari , K , Tammela , T L J & Auvinen , A 2018 , ' Fasting blood glucose, glycaemic control and prostate cancer risk in the Finnish Randomized Study of Screening for Prostate Cancer ' , British Journal of Cancer , vol. 118 , no. 9 , pp. 1248-1254 . https://doi.org/10.1038/s41416-018-0055-4

Title: Fasting blood glucose, glycaemic control and prostate cancer risk in the Finnish Randomized Study of Screening for Prostate Cancer
Author: Murtola, Teemu J.; Vihervuori, Ville J. Y.; Lahtela, Jorma; Talala, Kirsi; Taari, Kimmo; Tammela, Teuvo L. J.; Auvinen, Anssi
Contributor: University of Helsinki, Clinicum
Date: 2018-05
Language: eng
Number of pages: 7
Belongs to series: British Journal of Cancer
ISSN: 0007-0920
URI: http://hdl.handle.net/10138/302397
Abstract: BACKGROUND: Diabetic men have lowered overall risk of prostate cancer (PCa), but the role of hyperglycaemia is unclear. In this cohort study, we estimated PCa risk among men with diabetic fasting blood glucose level. METHODS: Participants of the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC) were linked to laboratory database for information on glucose measurements since 1978. The data were available for 17,860 men. Based on the average yearly level, the men were categorised as normoglycaemic, prediabetic, or diabetic. Median follow-up was 14.7 years. Multivariable-adjusted Cox regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for prostate cancer overall and separately by Gleason grade and metastatic stage. RESULTS: In total 1,663 PCa cases were diagnosed. Compared to normoglycaemic men, those men with diabetic blood glucose level had increased risk of PCa (HR 1.52; 95% CI 1.31-1.75). The risk increase was observed for all tumour grades, and persisted for a decade afterwards. Antidiabetic drug use removed the risk association. Limitations include absence of information on lifestyle factors and limited information on BMI. CONCLUSIONS: Untreated diabetic fasting blood glucose level may be a prostate cancer risk factor.
Subject: TYPE-2 DIABETES-MELLITUS
FOLLOW-UP
DRUG-USE
METAANALYSIS
MEN
HYPERINSULINEMIA
MORTALITY
TRIAL
3126 Surgery, anesthesiology, intensive care, radiology
3122 Cancers
3121 General medicine, internal medicine and other clinical medicine
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