Association of cytomegalovirus and Epstein-Barr virus with cognitive functioning and risk of dementia in the general population : 11-year follow-up study

Show full item record



Permalink

http://hdl.handle.net/10138/302418

Citation

Torniainen-Holm , M , Suvisaari , J , Lindgren , M , Härkänen , T , Dickerson , F & Yolken , R H 2018 , ' Association of cytomegalovirus and Epstein-Barr virus with cognitive functioning and risk of dementia in the general population : 11-year follow-up study ' , Brain, Behavior, and Immunity , vol. 69 , pp. 480-485 . https://doi.org/10.1016/j.bbi.2018.01.006

Title: Association of cytomegalovirus and Epstein-Barr virus with cognitive functioning and risk of dementia in the general population : 11-year follow-up study
Author: Torniainen-Holm, Minna; Suvisaari, Jaana; Lindgren, Maija; Härkänen, Tommi; Dickerson, Faith; Yolken, Robert H.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
Date: 2018-03
Language: eng
Number of pages: 6
Belongs to series: Brain, Behavior, and Immunity
ISSN: 0889-1591
URI: http://hdl.handle.net/10138/302418
Abstract: Background: Earlier studies have documented an association between cytomegalovirus and cognitive impairment, but results have been inconsistent. Few studies have investigated the association of cytomegalovirus and Epstein-Barr virus with cognitive decline longitudinally. Our aim was to examine whether cytomegalovirus and Epstein-Barr virus are associated with cognitive decline, in adults. Method: The study sample is from the Finnish Health 2000 Survey (BRIF8901, n = 7112), which is representative of the Finnish adult population. The sample was followed up after 11 years in the Health 2011 Survey. In addition, persons with dementia were identified from healthcare registers. Results: In the Finnish population aged 30 and over, the seroprevalence of cytomegalovirus was estimated to be 84% and the seroprevalence of Epstein-Barr virus 98%. Seropositivity of the viruses and antibody levels were mostly not associated with cognitive performance. In the middle-aged adult group, cytomegalovirus serointensity was associated with impaired performance in verbal learning. However, the association disappeared when corrected for multiple testing. No interactions between infection and time or between the two infections were significant when corrected for multiple testing. Seropositivity did not predict dementia diagnosis. Conclusions: The results suggest that adult levels of antibodies to cytomegalovirus and Epstein-Barr virus may not be associated with a significant decline in cognitive function or with dementia at population level. (C) 2018 Published by Elsevier Inc.
Subject: Cytomegalovirus
Epstein-Barr
CMV
EBV
Cognition
Dementia
Neuropsychology
Viral
Prevalence
ALZHEIMERS-DISEASE
INFECTION
SEROPREVALENCE
INDIVIDUALS
FINLAND
HEALTH
3112 Neurosciences
3124 Neurology and psychiatry
3121 Internal medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0889159118300072_main.pdf 458.7Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record