Kidney transplant outcomes from older deceased donors : a paired kidney analysis by the European Renal Association-European Dialysis and Transplant Association Registry

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Pippias , M , Jager , K J , Caskey , F , Casula , A , Erlandsson , H , Finne , P , Heaf , J , Heinze , G , Hoitsma , A , Kramar , R , Lempinen , M , Magaz , A , Midtvedt , K , Mumford , L L , Pascual , J , Prütz , K G , Sorensen , S S , Traynor , J P , Massy , Z A , Ravanan , R & Stel , V S 2018 , ' Kidney transplant outcomes from older deceased donors : a paired kidney analysis by the European Renal Association-European Dialysis and Transplant Association Registry ' , Transplant International , vol. 31 , no. 7 , pp. 708-719 . https://doi.org/10.1111/tri.13103

Title: Kidney transplant outcomes from older deceased donors : a paired kidney analysis by the European Renal Association-European Dialysis and Transplant Association Registry
Author: Pippias, Maria; Jager, Kitty J.; Caskey, Fergus; Casula, Anna; Erlandsson, Helen; Finne, Patrik; Heaf, James; Heinze, Georg; Hoitsma, Andries; Kramar, Reinhard; Lempinen, Marko; Magaz, Angela; Midtvedt, Karsten; Mumford, Lisa L.; Pascual, Julio; Prütz, Karl G.; Sorensen, Soren S.; Traynor, Jamie P.; Massy, Ziad A.; Ravanan, Rommel; Stel, Vianda S.
Contributor: University of Helsinki, Faculty of Medicine
University of Helsinki, IV kirurgian klinikka
Date: 2018-07
Language: eng
Number of pages: 12
Belongs to series: Transplant International
ISSN: 0934-0874
URI: http://hdl.handle.net/10138/302448
Abstract: As the median age of deceased kidney donors rises, updated knowledge of transplant outcomes from older deceased donors in differing donor-recipient age groups is required. Using ERA-EDTA Registry data we determined survival outcomes of kidney allografts donated from the same older deceased donor (55-70 years), and transplanted into one recipient younger and one recipient of similar age to the donor. The recipient pairs were divided into two groups: group 1; younger (median age: 52 years) and older (60 years) and group 2; younger (41 years) and older (60 years). A total of 1410 adults were transplanted during 2000-2007. Compared to the older recipients, the mean number of functioning graft years at 10 years was 6 months longer in the group 1 and group 2 younger recipients (P <0.001). Ten-year graft survival was 54% and 40% for the group 1 younger and older recipients, and 60% and 49% for the group 2 younger and older recipients. Paired Cox regression analyses showed a lower risk of graft failure (group 1 younger; adjusted relative risk [RRa]:0.57, 95% CI:0.41-0.79, and group 2 younger; RRa:0.63, 95% CI:0.47-0.85) in younger recipients. Outcomes from older deceased donor allografts transplanted into differing donor-recipient age groups are better than previously reported. These allografts remain a valuable transplant resource, particularly for similar-aged recipients.
Subject: deceased donors
donor age
graft survival
kidney transplant
registry
EXPANDED-CRITERIA DONORS
RECIPIENT AGE
SURVIVAL
3126 Surgery, anesthesiology, intensive care, radiology
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