A pilot study of hyperoxemia on neurological injury, inflammation and oxidative stress

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Lång , M , Skrifvars , M B , Siironen , J , Tanskanen , P , Ala-Peijari , M , Koivisto , T , Djafarzadeh , S & Bendel , S 2018 , ' A pilot study of hyperoxemia on neurological injury, inflammation and oxidative stress ' , Acta Anaesthesiologica Scandinavica , vol. 62 , no. 6 , pp. 801-810 . https://doi.org/10.1111/aas.13093

Title: A pilot study of hyperoxemia on neurological injury, inflammation and oxidative stress
Author: Lång, M.; Skrifvars, M. B.; Siironen, J.; Tanskanen, P.; Ala-Peijari, M.; Koivisto, T.; Djafarzadeh, S.; Bendel, S.
Contributor: University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, HUS Neurocenter
University of Helsinki, Anestesiologian yksikkö
Date: 2018-07
Language: eng
Number of pages: 10
Belongs to series: Acta Anaesthesiologica Scandinavica
ISSN: 0001-5172
URI: http://hdl.handle.net/10138/302450
Abstract: BackgroundNormobaric hyperoxia is used to alleviate secondary brain ischaemia in patients with traumatic brain injury (TBI), but clinical evidence is limited and hyperoxia may cause adverse events. MethodsAn open label, randomised controlled pilot study comparing blood concentrations of reactive oxygen species (ROS), interleukin 6 (IL-6) and neuron-specific enolase (NSE) between two different fractions of inspired oxygen in severe TBI patients on mechanical ventilation. ResultsWe enrolled 27 patients in the Fi O-2 0.40 group and 38 in the Fi O-2 0.70 group; 19 and 23 patients, respectively, completed biochemical analyses. In baseline, there were no differences between Fi O-2 0.40 and Fi O-2 0.70 groups, respectively, in ROS (64.8 nM [22.6-102.1] vs. 64.9 nM [26.8-96.3], P = 0.80), IL-6 (group 92.4 pg/ml [52.9-171.6] vs. 94.3 pg/ml [54.8-133.1], P = 0.52) or NSE (21.04 ug/l [14.0-30.7] vs. 17.8 ug/l [14.1-23.9], P = 0.35). ROS levels did not differ at Day 1 (24.2 nM [20.6-33.5] vs. 29.2 nM [22.7-69.2], P = 0.10) or at Day 2 (25.4 nM [21.7-37.4] vs. 47.3 nM [34.4-126.1], P = 0.95). IL-6 concentrations did not differ at Day 1 (112.7 pg/ml [65.9-168.9) vs. 83.9 pg/ml [51.8-144.3], P = 0.41) or at Day 3 (55.0 pg/ml [34.2-115.6] vs. 49.3 pg/ml [34.4-126.1], P = 0.95). NSE levels did not differ at Day 1 (15.9 ug/l [9.0-24.3] vs. 15.3 ug/l [12.2-26.3], P = 0.62). There were no differences between groups in the incidence of pulmonary complications. ConclusionHigher fraction of inspired oxygen did not increase blood concentrations of markers of oxidative stress, inflammation or neurological injury or the incidence of pulmonary complications in severe TBI patients on mechanical ventilation.
Subject: TRAUMATIC BRAIN-INJURY
ACUTE LUNG INJURY
NORMOBARIC HYPEROXIA
CRITICAL ILLNESS
OXYGEN-THERAPY
IMPACT
ASSOCIATION
METABOLISM
INCREASE
SYSTEM
3126 Surgery, anesthesiology, intensive care, radiology
3112 Neurosciences
3124 Neurology and psychiatry
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