Lång , M , Skrifvars , M B , Siironen , J , Tanskanen , P , Ala-Peijari , M , Koivisto , T , Djafarzadeh , S & Bendel , S 2018 , ' A pilot study of hyperoxemia on neurological injury, inflammation and oxidative stress ' , Acta Anaesthesiologica Scandinavica , vol. 62 , no. 6 , pp. 801-810 . https://doi.org/10.1111/aas.13093
Title: | A pilot study of hyperoxemia on neurological injury, inflammation and oxidative stress |
Author: | Lång, M.; Skrifvars, M. B.; Siironen, J.; Tanskanen, P.; Ala-Peijari, M.; Koivisto, T.; Djafarzadeh, S.; Bendel, S. |
Contributor organization: | Department of Diagnostics and Therapeutics Clinicum Anestesiologian yksikkö University of Helsinki HUS Perioperative, Intensive Care and Pain Medicine HUS Neurocenter Neurokirurgian yksikkö Department of Neurosciences |
Date: | 2018-07 |
Language: | eng |
Number of pages: | 10 |
Belongs to series: | Acta Anaesthesiologica Scandinavica |
ISSN: | 0001-5172 |
DOI: | https://doi.org/10.1111/aas.13093 |
URI: | http://hdl.handle.net/10138/302450 |
Abstract: | BackgroundNormobaric hyperoxia is used to alleviate secondary brain ischaemia in patients with traumatic brain injury (TBI), but clinical evidence is limited and hyperoxia may cause adverse events. MethodsAn open label, randomised controlled pilot study comparing blood concentrations of reactive oxygen species (ROS), interleukin 6 (IL-6) and neuron-specific enolase (NSE) between two different fractions of inspired oxygen in severe TBI patients on mechanical ventilation. ResultsWe enrolled 27 patients in the Fi O-2 0.40 group and 38 in the Fi O-2 0.70 group; 19 and 23 patients, respectively, completed biochemical analyses. In baseline, there were no differences between Fi O-2 0.40 and Fi O-2 0.70 groups, respectively, in ROS (64.8 nM [22.6-102.1] vs. 64.9 nM [26.8-96.3], P = 0.80), IL-6 (group 92.4 pg/ml [52.9-171.6] vs. 94.3 pg/ml [54.8-133.1], P = 0.52) or NSE (21.04 ug/l [14.0-30.7] vs. 17.8 ug/l [14.1-23.9], P = 0.35). ROS levels did not differ at Day 1 (24.2 nM [20.6-33.5] vs. 29.2 nM [22.7-69.2], P = 0.10) or at Day 2 (25.4 nM [21.7-37.4] vs. 47.3 nM [34.4-126.1], P = 0.95). IL-6 concentrations did not differ at Day 1 (112.7 pg/ml [65.9-168.9) vs. 83.9 pg/ml [51.8-144.3], P = 0.41) or at Day 3 (55.0 pg/ml [34.2-115.6] vs. 49.3 pg/ml [34.4-126.1], P = 0.95). NSE levels did not differ at Day 1 (15.9 ug/l [9.0-24.3] vs. 15.3 ug/l [12.2-26.3], P = 0.62). There were no differences between groups in the incidence of pulmonary complications. ConclusionHigher fraction of inspired oxygen did not increase blood concentrations of markers of oxidative stress, inflammation or neurological injury or the incidence of pulmonary complications in severe TBI patients on mechanical ventilation. |
Subject: |
TRAUMATIC BRAIN-INJURY
ACUTE LUNG INJURY NORMOBARIC HYPEROXIA CRITICAL ILLNESS OXYGEN-THERAPY IMPACT ASSOCIATION METABOLISM INCREASE SYSTEM 3126 Surgery, anesthesiology, intensive care, radiology 3112 Neurosciences 3124 Neurology and psychiatry |
Peer reviewed: | Yes |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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