Polymorphous adenocarcinoma of the salivary glands : reappraisal and update

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Vander Poorten , V , Triantafyllou , A , Skalova , A , Stenman , G , Bishop , J A , Hauben , E , Hunt , J L , Hellquist , H , Feys , S , De Bree , R , Mäkitie , A A , Quer , M , Strojan , P , Guntinas-Lichius , O , Rinaldo , A & Ferlito , A 2018 , ' Polymorphous adenocarcinoma of the salivary glands : reappraisal and update ' , European Archives of Oto-Rhino-Laryngology , vol. 275 , no. 7 , pp. 1681-1695 . https://doi.org/10.1007/s00405-018-4985-5

Title: Polymorphous adenocarcinoma of the salivary glands : reappraisal and update
Author: Vander Poorten, Vincent; Triantafyllou, Asterios; Skalova, Alena; Stenman, Göran; Bishop, Justin A.; Hauben, Esther; Hunt, Jennifer L.; Hellquist, Henrik; Feys, Simon; De Bree, Remco; Mäkitie, Antti A.; Quer, Miquel; Strojan, Primoz; Guntinas-Lichius, Orlando; Rinaldo, Alessandra; Ferlito, Alfio
Contributor: University of Helsinki, Clinicum
Date: 2018-07
Language: eng
Number of pages: 15
Belongs to series: European Archives of Oto-Rhino-Laryngology
ISSN: 0937-4477
URI: http://hdl.handle.net/10138/302452
Abstract: Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.
Subject: Polymorphous adenocarcinoma
Pathology
Salivary glands
Therapy
Prognosis
Polymorphous low-grade adenocarcinoma
Cribriform adenocarcinoma of minor salivary glands
LOW-GRADE ADENOCARCINOMA
ADENOID CYSTIC CARCINOMA
NEEDLE-ASPIRATION-CYTOLOGY
LYMPH-NODE METASTASIS
TERM-FOLLOW-UP
CRIBRIFORM ADENOCARCINOMA
NECK-CANCER
MALIGNANT-TUMORS
ORAL-CAVITY
CASE SERIES
3125 Otorhinolaryngology, ophthalmology
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