Multiscale Simulations of Biological Membranes : The Challenge To Understand Biological Phenomena in a Living Substance

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dc.contributor University of Helsinki, Materials Physics en
dc.contributor University of Helsinki, Department of Physics en
dc.contributor University of Helsinki, Materials Physics en
dc.contributor University of Helsinki, Department of Physics en
dc.contributor University of Helsinki, Department of Physics en
dc.contributor.author Enkavi, Giray
dc.contributor.author Javanainen, Matti
dc.contributor.author Kulig, Waldemar
dc.contributor.author Róg, Tomasz
dc.contributor.author Vattulainen, Ilpo
dc.date.accessioned 2019-06-04T13:02:02Z
dc.date.available 2019-06-04T13:02:02Z
dc.date.issued 2019-05-08
dc.identifier.citation Enkavi , G , Javanainen , M , Kulig , W , Róg , T & Vattulainen , I 2019 , ' Multiscale Simulations of Biological Membranes : The Challenge To Understand Biological Phenomena in a Living Substance ' , Chemical Reviews , vol. 119 , no. 9 , pp. 5607-5774 . https://doi.org/10.1021/acs.chemrev.8b00538 en
dc.identifier.issn 0009-2665
dc.identifier.other PURE: 124997049
dc.identifier.other PURE UUID: 8a5b6019-cc7d-42af-b6e2-2c25cc6a0976
dc.identifier.other RIS: urn:38C3C6A9BD65A6082B69B7A4C9456F89
dc.identifier.other Scopus: 85063142928
dc.identifier.other WOS: 000483128100001
dc.identifier.other ORCID: /0000-0001-7568-0029/work/58267075
dc.identifier.other ORCID: /0000-0001-7408-3214/work/58267193
dc.identifier.other ORCID: /0000-0003-4858-364X/work/58267454
dc.identifier.uri http://hdl.handle.net/10138/302524
dc.description.abstract Biological membranes are tricky to investigate. They are complex in terms of molecular composition and structure, functional over a wide range of time scales, and characterized by nonequilibrium conditions. Because of all of these features, simulations are a great technique to study biomembrane behavior. A significant part of the functional processes in biological membranes takes place at the molecular level; thus computer simulations are the method of choice to explore how their properties emerge from specific molecular features and how the interplay among the numerous molecules gives rise to function over spatial and time scales larger than the molecular ones. In this review, we focus on this broad theme. We discuss the current state-of-the-art of biomembrane simulations that, until now, have largely focused on a rather narrow picture of the complexity of the membranes. Given this, we also discuss the challenges that we should unravel in the foreseeable future. Numerous features such as the actin-cytoskeleton network, the glycocalyx network, and nonequilibrium transport under ATP-driven conditions have so far received very little attention; however, the potential of simulations to solve them would be exceptionally high. A major milestone for this research would be that one day we could say that computer simulations genuinely research biological membranes, not just lipid bilayers. en
dc.format.extent 168
dc.language.iso eng
dc.relation.ispartof Chemical Reviews
dc.rights en
dc.subject 114 Physical sciences en
dc.subject 116 Chemical sciences en
dc.title Multiscale Simulations of Biological Membranes : The Challenge To Understand Biological Phenomena in a Living Substance en
dc.type Review Article
dc.identifier.doi https://doi.org/10.1021/acs.chemrev.8b00538
dc.type.uri info:eu-repo/semantics/other
dc.contributor.pbl
dc.contributor.pbl

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