Extracellular peptide Kratos restricts cell death during vascular development and stress in Arabidopsis

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Escamez , S , Stael , S , Vainonen , J , Willems , P , Jin , H , Kimura , S , Van Breusegem , F , Gevaert , K , Wrzaczek , M A & Tuominen , H 2019 , ' Extracellular peptide Kratos restricts cell death during vascular development and stress in Arabidopsis ' , Journal of Experimental Botany , vol. 70 , no. 7 , pp. 2199-2210 . https://doi.org/10.1093/jxb/erz021

Title: Extracellular peptide Kratos restricts cell death during vascular development and stress in Arabidopsis
Author: Escamez, Sacha; Stael, Simon; Vainonen, Julia; Willems, Patrick; Jin, Huiting; Kimura, Sachie; Van Breusegem, Frank; Gevaert, Kris; Wrzaczek, Michael Alois; Tuominen, Hannele
Contributor: University of Helsinki, Organismal and Evolutionary Biology Research Programme
University of Helsinki, Organismal and Evolutionary Biology Research Programme
University of Helsinki, Organismal and Evolutionary Biology Research Programme
University of Helsinki, Viikki Plant Science Centre (ViPS)
Date: 2019-03-15
Language: eng
Number of pages: 12
Belongs to series: Journal of Experimental Botany
ISSN: 0022-0957
URI: http://hdl.handle.net/10138/302550
Abstract: During plant vascular development, xylem tracheary elements (TEs) form water-conducting, empty pipes by genetically regulated cell death. Cell death is prevented from spreading to non-TEs by unidentified intercellular mechanisms, downstream of METACASPASE9 (MC9)-mediated regulation of autophagy in TEs. Here, we identified differentially abundant extracellular peptides in vascular-differentiating wild-type and MC9-down-regulated Arabidopsis cell suspensions. A peptide named Kratos rescued the abnormally high ectopic non-TE death resulting from either MC9 knockout or TE-specific overexpression of the ATG5 autophagy protein during experimentally induced vascular differentiation in Arabidopsis cotyledons. Kratos also reduced cell death following mechanical damage and extracellular ROS production in Arabidopsis leaves. Stress-induced but not vascular non-TE cell death was enhanced by another identified peptide, named Bia. Bia is therefore reminiscent of several known plant cell death-inducing peptides acting as damage-associated molecular patterns. In contrast, Kratos plays a novel extracellular cell survival role in the context of development and during stress response.
Subject: APOPTOSIS
AUTOLYSIS
AUTOPHAGY
Arabidopsis
IDENTIFICATION
INFLAMMATION
MECHANISM
PATHWAY
PROTEIN
REVEALS
SPREAD
autophagy
cell death
peptide
peptidomics
programmed cell death
stress response
vascular development
xylem
1183 Plant biology, microbiology, virology
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