The viral protein corona directs viral pathogenesis and amyloid aggregation

Show full item record



Ezzat , K , Pernemalm , M , Palsson , S , Roberts , T C , Järver , P , Dondalska , A , Bestas , B , Sobkowiak , M J , Levänen , B , Sköld , M , Thompson , E A , Saher , O , Kari , O K , Lajunen , T , Ekstrom , E S , Nilsson , C , Ishchenko , Y , Malm , T , Wood , M J A , Power , U F , Masich , S , Linden , A , Sandberg , J K , Lehtiö , J , Spetz , A-L & EL Andaloussi , S 2019 , ' The viral protein corona directs viral pathogenesis and amyloid aggregation ' , Nature Communications , vol. 10 , 2331 .

Title: The viral protein corona directs viral pathogenesis and amyloid aggregation
Author: Ezzat, Kariem; Pernemalm, Maria; Palsson, Sandra; Roberts, Thomas C.; Järver, Peter; Dondalska, Aleksandra; Bestas, Burcu; Sobkowiak, Michal J.; Levänen, Bettina; Sköld, Magnus; Thompson, Elizabeth A.; Saher, Osama; Kari, Otto K.; Lajunen, Tatu; Ekstrom, Eva Sverremark; Nilsson, Caroline; Ishchenko, Yevheniia; Malm, Tarja; Wood, Matthew J. A.; Power, Ultan F.; Masich, Sergej; Linden, Anders; Sandberg, Johan K.; Lehtiö, Janne; Spetz, Anna-Lena; EL Andaloussi, Samir
Contributor organization: Division of Pharmaceutical Biosciences
Drug Delivery Unit
Drug Research Program
Pharmaceutical Nanotechnology
Date: 2019-05-27
Language: eng
Number of pages: 16
Belongs to series: Nature Communications
ISSN: 2041-1723
Abstract: Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid beta-peptide (A beta(42)), a major constituent of amyloid plaques in Alzheimer's disease, in vitro and in animal models. Our results highlight the viral protein corona as an acquired structural layer that is critical for viral-host interactions and illustrate a mechanistic convergence between viral and amyloid pathologies.
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
s41467_019_10192_2.pdf 4.229Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record