The viral protein corona directs viral pathogenesis and amyloid aggregation

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http://hdl.handle.net/10138/302827

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Ezzat , K , Pernemalm , M , Palsson , S , Roberts , T C , Järver , P , Dondalska , A , Bestas , B , Sobkowiak , M J , Levänen , B , Sköld , M , Thompson , E A , Saher , O , Kari , O K , Lajunen , T , Ekstrom , E S , Nilsson , C , Ishchenko , Y , Malm , T , Wood , M J A , Power , U F , Masich , S , Linden , A , Sandberg , J K , Lehtiö , J , Spetz , A-L & EL Andaloussi , S 2019 , ' The viral protein corona directs viral pathogenesis and amyloid aggregation ' , Nature Communications , vol. 10 , 2331 . https://doi.org/10.1038/s41467-019-10192-2

Titel: The viral protein corona directs viral pathogenesis and amyloid aggregation
Författare: Ezzat, Kariem; Pernemalm, Maria; Palsson, Sandra; Roberts, Thomas C.; Järver, Peter; Dondalska, Aleksandra; Bestas, Burcu; Sobkowiak, Michal J.; Levänen, Bettina; Sköld, Magnus; Thompson, Elizabeth A.; Saher, Osama; Kari, Otto K.; Lajunen, Tatu; Ekstrom, Eva Sverremark; Nilsson, Caroline; Ishchenko, Yevheniia; Malm, Tarja; Wood, Matthew J. A.; Power, Ultan F.; Masich, Sergej; Linden, Anders; Sandberg, Johan K.; Lehtiö, Janne; Spetz, Anna-Lena; EL Andaloussi, Samir
Upphovmannens organisation: Division of Pharmaceutical Biosciences
Drug Delivery Unit
Drug Research Program
Pharmaceutical Nanotechnology
Datum: 2019-05-27
Språk: eng
Sidantal: 16
Tillhör serie: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-019-10192-2
Permanenta länken (URI): http://hdl.handle.net/10138/302827
Abstrakt: Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid beta-peptide (A beta(42)), a major constituent of amyloid plaques in Alzheimer's disease, in vitro and in animal models. Our results highlight the viral protein corona as an acquired structural layer that is critical for viral-host interactions and illustrate a mechanistic convergence between viral and amyloid pathologies.
Subject: RESPIRATORY SYNCYTIAL VIRUS
BETA
RECEPTOR
NANOPARTICLES
INFECTION
IMMUNITY
OPPORTUNITIES
FIBRILLATION
FIBRINOGEN
RISK
3111 Biomedicine
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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