Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss

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Sarin , H V , Gudelj , I , Honkanen , J , Ihalainen , J K , Vuorela , A , Lee , J H , Jin , Z , Terwilliger , J D , Isola , V , Ahtiainen , J P , Häkkinen , K , Juric , J , Lauc , G , Kristiansson , K , Hulmi , J J & Perola , M 2019 , ' Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss ' , Frontiers in Immunology , vol. 10 , 907 . https://doi.org/10.3389/fimmu.2019.00907

Title: Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss
Author: Sarin, Heikki V.; Gudelj, Ivan; Honkanen, Jarno; Ihalainen, Johanna K.; Vuorela, Arja; Lee, Joseph H.; Jin, Zhenzhen; Terwilliger, Joseph D.; Isola, Ville; Ahtiainen, Juha P.; Häkkinen, Keijo; Juric, Julija; Lauc, Gordan; Kristiansson, Kati; Hulmi, Juha J.; Perola, Markus
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, University of Helsinki
University of Helsinki, Clinicum
University of Helsinki, Quantitative Genetics
University of Helsinki, Department of Physiology
University of Helsinki, Research Programs Unit
Date: 2019-05-03
Language: eng
Number of pages: 17
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
URI: http://hdl.handle.net/10138/303436
Abstract: Exercise and exercise-induced weight loss have a beneficial effect on overall health, including positive effects on molecular pathways associated with immune function, especially in overweight individuals. The main aim of our study was to assess how energy deprivation (i.e., "semi-starvation") leading to substantial fat mass loss affects the immune system and immunosuppression in previously normal weight individuals. Thus, to address this hypothesis, we applied a high-throughput systems biology approach to better characterize potential key pathways associated with immune system modulation during intensive weight loss and subsequent weight regain. We examined 42 healthy female physique athletes (age 27.5 +/- 4.0 years, body mass index 23.4 +/- 1.7 kg/m(2)) volunteered into either a diet group (n = 25) or a control group (n = 17). For the diet group, the energy intake was reduced and exercise levels were increased to induce loss of fat mass that was subsequently regained during a recovery period. The control group was instructed to maintain their typical lifestyle, exercise levels, and energy intake at a constant level. For quantification of systems biology markers, fasting blood samples were drawn at three time points: baseline (PRE), at the end of the weight loss period (MID 21.1 +/- 3.1 weeks after PRE), and at the end of the weight regain period (POST 18.4 +/- 2.9 weeks after MID). In contrast to the control group, the diet group showed significant (false discovery rate
Subject: immunosuppression
low energy availability
physical training
bioinformatics
weight loss
HEMATOPOIETIC STEM
DIETARY RESTRICTION
OXIDATIVE STRESS
IMMUNE FUNCTION
OBESITY
LEPTIN
CELLS
INFLAMMATION
CYTOKINES
EXERCISE
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
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