Influenza and associated co-infections in critically ill immunosuppressed patients

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http://hdl.handle.net/10138/303443

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Efraim Investigators , Nine-I Study Grp , Martin-Loeches , I , Valkonen , M & Azoulay , E 2019 , ' Influenza and associated co-infections in critically ill immunosuppressed patients ' , Critical Care , vol. 23 , 152 . https://doi.org/10.1186/s13054-019-2425-6

Title: Influenza and associated co-infections in critically ill immunosuppressed patients
Author: Efraim Investigators; Nine-I Study Grp; Martin-Loeches, Ignacio; Valkonen, Miia; Azoulay, Elie
Contributor: University of Helsinki, Anestesiologian yksikkö
Date: 2019-05-02
Language: eng
Number of pages: 10
Belongs to series: Critical Care
ISSN: 1466-609X
URI: http://hdl.handle.net/10138/303443
Abstract: BackgroundIt is unclear whether influenza infection and associated co-infection are associated with patient-important outcomes in critically ill immunocompromised patients with acute respiratory failure.MethodsPreplanned secondary analysis of EFRAIM, a prospective cohort study of 68 hospitals in 16 countries. We included 1611 patients aged 18years or older with non-AIDS-related immunocompromise, who were admitted to the ICU with acute hypoxemic respiratory failure. The main exposure of interest was influenza infection status. The primary outcome of interest was all-cause hospital mortality, and secondary outcomes ICU length of stay (LOS) and 90-day mortality.ResultsInfluenza infection status was categorized into four groups: patients with influenza alone (n=95, 5.8%), patients with influenza plus pulmonary co-infection (n=58, 3.6%), patients with non-influenza pulmonary infection (n=820, 50.9%), and patients without pulmonary infection (n=638, 39.6%). Influenza infection status was associated with a requirement for intubation and with LOS in ICU (P
Subject: Influenza
Respiratory failure
Sepsis
Critical illness
Immunosuppression
BACTERIAL COINFECTION
RESPIRATORY-FAILURE
SEPSIS
MALIGNANCY
MANAGEMENT
PNEUMONIA
INFECTION
IMPACT
3121 Internal medicine
3126 Surgery, anesthesiology, intensive care, radiology
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