Ullanlinna Narcolepsy Scale in diagnosis of narcolepsy

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Sarkanen , T , Alakuijala , A & Partinen , M 2019 , ' Ullanlinna Narcolepsy Scale in diagnosis of narcolepsy ' , Sleep , vol. 42 , no. 3 , 238 . https://doi.org/10.1093/sleep/zsy238

Title: Ullanlinna Narcolepsy Scale in diagnosis of narcolepsy
Author: Sarkanen, Tomi; Alakuijala, Anniina; Partinen, Markku
Contributor organization: Department of Neurosciences
Clinicum
Neurologian yksikkö
Kliinisen neurofysiologian yksikkö
Department of Diagnostics and Therapeutics
HUS Medical Imaging Center
HUS Neurocenter
Date: 2019-03
Language: eng
Number of pages: 7
Belongs to series: Sleep
ISSN: 0161-8105
DOI: https://doi.org/10.1093/sleep/zsy238
URI: http://hdl.handle.net/10138/303482
Abstract: Study objectives To validate Ullanlinna Narcolepsy Scale (UNS) as a screening tool for narcolepsy in a clinical population and to compare it with Swiss Narcolepsy Scale (SNS) and Epworth Sleepiness Scale (ESS). Methods UNS questionnaires of 267 participants visiting Helsinki Sleep Clinic were analyzed. The diagnoses of the participants were narcolepsy type 1 (NT1, n = 89), narcolepsy type 2 (NT2, n = 10), other hypersomnias (n = 24), sleep apnea (n = 37), restless legs syndrome or periodic limb movement disorder (n = 56), and other sleep-related disorders (n = 51). In addition, ESS and SNS scores in a subset of sample (total N = 167) were analyzed and compared to UNS. Results Mean UNS score in NT1 was 22.0 (95% confidence interval [CI] = 20.4 to 23.6, range 9-43), which was significantly higher than in other disorders, including NT2 (mean 13.7, 95% CI = 10.3 to 17.1, range 7-21, p = .0013). Sensitivity and specificity of UNS in separating NT1 from other disorders were 83.5% and 84.1%, respectively. Positive and negative predictive values were 82.5% and 85.1%, respectively. Sensitivities of SNS and ESS in NT1 were 77.2% and 88.6%, and specificities 88.6% and 45.5%, respectively. There were no differences in receiver operating characteristic curves between UNS and SNS. UNS had moderate negative correlation with hypocretin-1 levels (r(s) = -.564, p <.001), and mean sleep latency in multiple sleep latency test (r(s)= -.608, p <.001). Conclusions UNS has high specificity and sensitivity for NT1 in a sleep clinic setting. UNS scores below 9 strongly suggest against the diagnosis of narcolepsy.
Subject: narcolepsy
cataplexy
hypersomnolence
idiopathic
sleep apnea
disorders of excessive somnolence
surveys and questionnaires
Ullanlinna Narcolepsy Scale
Swiss Narcolepsy Scale
EPWORTH SLEEPINESS SCALE
HYPOCRETIN-1 DEFICIENT PATIENTS
LATENCY TEST MSLT
SWISS NARCOLEPSY
VALID TOOL
IDENTIFICATION
SYMPTOMS
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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