Quantifying Complex Micro-Topography of Degenerated Articular Cartilage Surface by Contrast-Enhanced Micro-Computed Tomography and Parametric Analyses

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Ylitalo , T , Finnilä , M A J , Gahunia , H K , Karhula , S S , Suhonen , H , Valkealahti , M , Lehenkari , P , Haeggström , E , Pritzker , K P H , Saarakkala , S & Nieminen , H J 2019 , ' Quantifying Complex Micro-Topography of Degenerated Articular Cartilage Surface by Contrast-Enhanced Micro-Computed Tomography and Parametric Analyses ' , Journal of Orthopaedic Research , vol. 37 , no. 4 , pp. 855-866 . https://doi.org/10.1002/jor.24245

Title: Quantifying Complex Micro-Topography of Degenerated Articular Cartilage Surface by Contrast-Enhanced Micro-Computed Tomography and Parametric Analyses
Author: Ylitalo, Tuomo; Finnilä, Mikko A. J.; Gahunia, Harpal K.; Karhula, Sakari S.; Suhonen, Heikki; Valkealahti, Maarit; Lehenkari, Petri; Haeggström, Edward; Pritzker, Kenneth P. H.; Saarakkala, Simo; Nieminen, Heikki J.
Contributor: University of Helsinki, Materials Physics
University of Helsinki, Department of Physics
University of Helsinki, Department of Physics
University of Helsinki, Department of Physics
Date: 2019-04
Language: eng
Number of pages: 12
Belongs to series: Journal of Orthopaedic Research
ISSN: 0736-0266
URI: http://hdl.handle.net/10138/303493
Abstract: One of the earliest changes in osteoarthritis (OA) is a surface discontinuity of the articular cartilage (AC), and these surface changes become gradually more complex with OA progression. We recently developed a contrast enhanced micro-computed tomography (mu CT) method for visualizing AC surface in detail. The present study aims to introduce a mu CT analysis technique to parameterize these complex AC surface features and to demonstrate the feasibility of using these parameters to quantify degenerated AC surface. Osteochondral plugs (n = 35) extracted from 19 patients undergoing joint surgery were stained with phosphotungstic acid and imaged using mu CT. The surface micro-topography of AC was analyzed with developed method. Standard root mean square roughness (R-q) was calculated as a reference, and the Area Under Curve (AUC) for receiver operating characteristic analysis was used to compare the acquired quantitative parameters with semi-quantitative visual grading of mu CT image stacks. The parameters quantifying the complex micro-topography of AC surface exhibited good sensitivity and specificity in identifying surface continuity (AUC: 0.93, [0.80 0.99]), fissures (AUC: 0.94, [0.83 0.99]) and fibrillation (AUC: 0.98, [0.88 1.0]). Standard R-q was significantly smaller compared with the complex roughness (CRq) already with mild surface changes with all surface reference parameters - continuity, fibrillation, and fissure sum. Furthermore, only CRq showed a significant difference when comparing the intact surface with lowest fissure sum score. These results indicate that the presented method for evaluating complex AC surfaces exhibit potential to identify early OA changes in superficial AC and is dynamic throughout OA progression. (c) 2019 The Authors. Journal of Orthopaedic Research (R) Published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. Society. 9999:1-12, 2019.
Subject: articular cartilage
topography
surface roughness
3D imaging
microcomputed X-ray tomography
QUANTITATIVE ASSESSMENT
CT ARTHROGRAPHY
OSTEOARTHRITIS
ROUGHNESS
ULTRASOUND
THICKNESS
QUANTIFICATION
MORPHOLOGY
DIAGNOSIS
MRI
3126 Surgery, anesthesiology, intensive care, radiology
114 Physical sciences
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