Sick and grumpy: changes in social behaviour after a controlled immune stimulation in group-housed gilts

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Munsterhjelm , C M , Nordgreen , J , Aae , F , Heinonen , M L , Valros , A E & Janczak , A M 2019 , ' Sick and grumpy: changes in social behaviour after a controlled immune stimulation in group-housed gilts ' , Physiology & Behavior , vol. 198 , pp. 76-83 . https://doi.org/10.1016/j.physbeh.2018.09.018

Title: Sick and grumpy: changes in social behaviour after a controlled immune stimulation in group-housed gilts
Author: Munsterhjelm, Camilla Marianne; Nordgreen, Janicke; Aae, F.; Heinonen, Mari Leena; Valros, Anna Elisabet; Janczak, A. M.
Contributor: University of Helsinki, Departments of Faculty of Veterinary Medicine
University of Helsinki, Mari Heinonen / Principal Investigator
University of Helsinki, Laura Hänninen / Principal Investigator
Date: 2019-01-01
Language: eng
Number of pages: 8
Belongs to series: Physiology & Behavior
ISSN: 0031-9384
URI: http://hdl.handle.net/10138/303588
Abstract: Poor health is associated with an increased risk of tail biting outbreaks in pigs. We propose that this is because illness changes social dynamics either by changing the behaviour of the sick pig towards its penmates, the behaviour of the healthy penmates towards the sick pig, or both. We tested the effect of immune stimulation (lipopolysaccharide (LPS) injection: O111:B4; 1.5 mu g kg(-1) IV) on social behaviour in gilts housed in triplets in a cross-over experiment. Each pen was subjected to the control treatment (all three pigs injected with saline) and then LPS treatment (one pig injected with LPS, two injected with saline), or vice versa. LPS injected pigs had a shift in social motivation and performed more tail- and ear- directed behaviour than saline pigs two days after injection. They seemed to fit the description of 'sick and grumpy'. This change was seen about 40 h after the signs of acute illness dissipated and was not accompanied by a similar increase in activity. We discuss possible mechanisms for this behavioural change in light of changes in neurotransmitter levels at three days after LPS injection described in a previous experiment.
Subject: CANCER-PATIENTS
CYTOKINE
DEPRESSION
INFLAMMATORY MARKERS
INTERFERON-ALPHA
INTERLEUKIN-2
LPS
NEUROINFLAMMATION
PIGS
Pig
RISK-FACTORS
Sickness behaviour
Social behaviour
Sus scrofa
Tail biting
413 Veterinary science
515 Psychology
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