Beyond good and evil: a putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment

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Diniz , C R A F , Casarotto , P C , Resstel , L & Samia , R L J 2018 , ' Beyond good and evil: a putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment ' , Neuroscience & Biobehavioral Reviews , vol. 90 , pp. 70-83 . https://doi.org/10.1016/j.neubiorev.2018.04.001

Title: Beyond good and evil: a putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment
Author: Diniz, Cassiano R.A.F.; Casarotto, Plinio C.; Resstel, Leonardo; Samia, R.L. Joca
Contributor: University of Helsinki, Neuroscience Center
Date: 2018-07
Language: eng
Number of pages: 14
Belongs to series: Neuroscience & Biobehavioral Reviews
ISSN: 0149-7634
URI: http://hdl.handle.net/10138/303651
Abstract: Depression and posttraumatic stress disorder are assumed to be maladaptive responses to stress and antidepressants are thought to counteract such responses by increasing BDNF (brain-derived neurotrophic factor) levels. BDNF acts through TrkB (tropomyosin-related receptor kinase B) and plays a central role in neuroplasticity. In contrast, both precursor proBDNF and BDNF propeptide (another metabolic product from proBDNF cleavage) have a high affinity to p75 receptor (p75R) and usually convey apoptosis and neuronal shrinkage. Although BDNF and proBDNF/propeptide apparently act in opposite ways, neuronal turnover and remodeling might be a final common way that both act to promote more effective neuronal networking, avoiding neuronal redundancy and the misleading effects of environmental contingencies. This review aims to provide a brief overview about the BDNF functional role in antidepressant action and about p75R and TrkB signaling to introduce the "continuum-sorting hypothesis." The resulting hypothesis suggests that both BDNF/proBDNF and BDNF/propeptide act as protagonists to fine-tune antidepressant-dependent neuroplasticity in crucial brain structures to modulate behavioral responses to stress.
Subject: 3112 Neurosciences
BDNF
proBDNF/BDNF-propeptide
stress
binary sorting hypothesis
depression
PTSD
P75 NEUROTROPHIN RECEPTOR
FACTOR MESSENGER-RNA
Depression
ELEMENT-BINDING PROTEIN
Stress
REGULATES HIPPOCAMPAL NEUROGENESIS
NERVE GROWTH-FACTOR
BDNF KNOCKOUT MICE
Continuum-sorting hypothesis
LONG-TERM DEPRESSION
MEDIAL PREFRONTAL CORTEX
FLUOXETINE TREATMENT INCREASES
DENTATE GYRUS
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