Delivery of an LGA infant and the maternal risk of diabetes: A prospective cohort study

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Hakkarainen , H , Huopio , H , Cederberg , H , Voutilainen , R & Heinonen , S 2018 , ' Delivery of an LGA infant and the maternal risk of diabetes: A prospective cohort study ' , Primary Care Diabetes , vol. 12 , no. 4 , pp. 364-370 .

Title: Delivery of an LGA infant and the maternal risk of diabetes: A prospective cohort study
Author: Hakkarainen, Heidi; Huopio, Hanna; Cederberg, Henna; Voutilainen, Raimo; Heinonen, Seppo
Contributor organization: Department of Medicine
Department of Obstetrics and Gynecology
University of Helsinki
HUS Gynecology and Obstetrics
HUS Internal Medicine and Rehabilitation
Date: 2018-08
Language: eng
Number of pages: 7
Belongs to series: Primary Care Diabetes
ISSN: 1751-9918
Abstract: Aims: Was to determine whether the birth weight of the infant predicts prediabetes (impaired fasting glucose, impaired glucose tolerance, or both) and type 2 diabetes (T2DM) during long-term follow-up of women with or without gestational diabetes mellitus (GDM). Methods: The women with or without GDM during their pregnancies in Kuopio University Hospital in 1989-2009 (n=876) were contacted and invited for an evaluation. They were stratified into two groups according to the newborn's birth weight: 10-90th percentile (appropriate-for-gestational-age; AGA) (n = 662) and >90th percentile (large-for-gestational-age; LGA) (n = 116). Glucose tolerance was investigated with an oral glucose tolerance test after a mean follow-up time of 7.3 (SD 5.1) years. Results: The incidence of T2DM was 11.8% and 0% in the women with and without GDM, respectively, after an LGA delivery. The incidence of prediabetes increased with offspring birth weight categories in the women with and without GDM: from 46.3% and 26.2% (AGA) to 52.9% and 29.2% (LGA), respectively. Conclusions: GDM women with LGA infants are at an increased risk for subsequent development of T2DM and therefore represent a target group for intervention to delay or prevent T2DM development. In contrast, an LGA delivery without GDM does not increase T2DM risk. (C) 2018 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
Subject: 3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Gestational diabetes mellitus
Type 2 diabetes
Birth weight
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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