Obstetric and perinatal health outcomes related to schizophrenia : A national register-based follow-up study among Finnish women born between 1965 and 1980 and their offspring

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Simoila , L , Isometsä , E , Gissler , M , Suvisaari , J , Halmesmäki , E & Lindberg , N 2018 , ' Obstetric and perinatal health outcomes related to schizophrenia : A national register-based follow-up study among Finnish women born between 1965 and 1980 and their offspring ' , European Psychiatry , vol. 52 , pp. 68-75 . https://doi.org/10.1016/j.eurpsy.2018.04.001

Title: Obstetric and perinatal health outcomes related to schizophrenia : A national register-based follow-up study among Finnish women born between 1965 and 1980 and their offspring
Author: Simoila, Laura; Isometsä, Erkki; Gissler, Mika; Suvisaari, Jaana; Halmesmäki, Erja; Lindberg, Nina
Contributor: University of Helsinki, Department of Psychiatry
University of Helsinki, Department of Psychiatry
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, University of Helsinki
Date: 2018-08
Language: eng
Number of pages: 8
Belongs to series: European Psychiatry
ISSN: 0924-9338
URI: http://hdl.handle.net/10138/303665
Abstract: Background: This national register-based study assesses obstetric and perinatal health outcomes in women with schizophrenia and their offspring. Methods: Using the Care Register for Health Care, we identified Finnish women who were born in 19651980 and diagnosed with schizophrenia. For each case, five age-and place-of-birth-matched controls were obtained from the Central Population Register of Finland. They were followed from the day when the disorder was diagnosed in specialized health-care (the index day) until 31.12.2013. Information related to births was obtained from the Medical Birth Register and the Register of Congenital Malformations. We focused on singleton pregnancies that led to a delivery after the index day. We restricted the analysis of deliveries in controls to those that occurred after the index day of the case. Maternal age, marital status, smoking status, sex of the newborn, and parity were used as covariates in adjusted models. Results: We identified 1162 singleton births among women with schizophrenia and 4683 among controls. Schizophrenic women had a 1.4-fold increased risk of induction of labor, delivery by cesarean section, and delivery by elective cesarean section. Regarding offspring, the risk of premature birth and the risk of low Apgar score at 1 min ( Conclusions: Schizophrenia associates with some specific delivery methods, but delivery complications are rare and their prevalence does not differ from that observed among community women. Maternal schizophrenia associates with some negative perinatal health outcomes of the offspring. (c) 2018 Elsevier Masson SAS. All rights reserved.
Subject: Delivery
Pregnancy
Postpartum period
Schizoaffective disorder
Schizophrenia
SEROTONIN REUPTAKE INHIBITORS
SMOKING-CESSATION
MENTAL-ILLNESS
CONGENITAL-MALFORMATIONS
BIRTH COHORT
PREGNANCY
CHILDREN
INFANT
COMPLICATIONS
PEOPLE
3124 Neurology and psychiatry
3123 Gynaecology and paediatrics
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